⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1337290 | 0.81 | MAPT (0.53) | — | |
| Hydrochloric Acid SCHEMBL1091453 | 0.79 | MAPT (0.52) | — | |
| SCHEMBL8795345 | 0.79 | MAPT (0.61) | — | |
| SCHEMBL1686631 | 0.79 | FADS1 (0.59) | — | |
| SCHEMBL11527837 | 0.78 | MAPT (0.56) | — | |
| SCHEMBL5158903 | 0.77 | — | — | |
| SCHEMBL24300038 | 0.75 | — | — | |
| SCHEMBL21835149 | 0.75 | — | — | |
| SCHEMBL19334340 | 0.75 | — | — | |
| SCHEMBL357405 | 0.75 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 89 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109293503-A | A kind of preparation method of the fluoro- 3- chlorobenzoic acid of 2,4,5- tri- | 浙江工业大学上虞研究院有限公司 | 2019-02-01 | — | — | CN | claimed |
| CN-106008372-B | A kind of preparation method and its key intermediate for replacing Buddhist nun up to grammeter | 江苏悦兴药业有限公司 | 2019-01-15 | — | — | CN | claimed |
| CN-106349084-B | A kind of preparation method of the fluoro- 3- chloroanilines of 4- | 安徽省虹升生物股份有限公司 | 2018-08-07 | — | — | CN | claimed |
| CN-107417592-A | A kind of oxoaGetamide derivative of 1H indoles 2 and preparation method and application | 浙江师范大学行知学院 | 2017-12-01 | — | — | CN | claimed |
| CN-107098895-A | Phenylamino thiazole methyl qualone derivative and preparation method and application | 湖南大学 | 2017-08-29 | — | — | CN | claimed |
| CN-106349084-A | Preparation method of 4-fluoro-3-chloroaniline | 安徽省虹升生物股份有限公司 | 2017-01-25 | — | — | CN | claimed |
| CN-103288808-B | A kind of Ah method is for the preparation method of Buddhist nun | SUZHOU MINGYUE MEDICAL TECHNOLOGY CO., LTD. (CN) | 2015-11-11 | — | — | CN | claimed |
| CN-103254183-B | Ah method is for the preparation method of Buddhist nun | SUZHOU MINGYUE MEDICAL TECHNOLOGY CO., LTD. (CN) | 2015-11-11 | — | — | CN | claimed |
| CN-102898386-B | Quinazoline derivant, its preparation method, intermediate, composition and application thereof | SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. (CN) | 2015-07-29 | — | — | CN | claimed |
| CN-103288759-B | Method for preparing dacomitinib | SUZHOU MIRACPHARMA TECHNOLOGY CO LTD | 2015-05-20 | — | — | CN | claimed |
| CN-104592116-A | 1,3,5-trisubstituted pyrazole compounds, and preparation method and application thereof | UNIV SHANDONG | 2015-05-06 | — | — | CN | claimed |
| CN-103242244-B | Canertinib preparation method | SUZHOU MINGRUI MEDICAL TECHNOLOGY CO LTD | 2015-03-25 | — | — | CN | claimed |
| CN-103242303-B | Afatinib preparation method | SUZHOU MINGRUI MEDICAL TECHNOLOGY CO LTD | 2015-03-25 | — | — | CN | claimed |
| CN-103288760-B | Preparation method of canertinib (I) | SUZHOU MIRACPHARMA TECHNOLOGY CO LTD | 2015-02-18 | — | — | CN | claimed |
| CN-103288758-B | Preparation method of dacomitinib (I) | SUZHOU MINGRUI PHARMACEUTICAL TECHNOLOGY CO LTD | 2015-01-21 | — | — | CN | claimed |
| CN-104003939-A | Diaryl substituted glycolythiourea compounds as well as preparation method and application thereof | UNIV SHANDONG | 2014-08-27 | — | — | CN | claimed |
| CN-103951584-A | Derivative of 3-chloro-N-phenyl-4-(3, 3, 3-trifluoro-2-methyl-2-hydroxy acrylic amide) benzamide and preparation method and application thereof | UNIV TSINGHUA | 2014-07-30 | — | — | CN | claimed |
| CN-103237801-A | Quinoline or quinazoline derivatives having apoptosis-inducing activity on cells | HANMI HOLDINGS CO LTD | 2013-08-07 | — | — | CN | claimed |
| CN-113200956-B | Sulfabenzamide derivative and preparation method and application thereof | 潍坊医学院 | 2022-04-22 | — | — | CN | disclosed |
| US-6002008-A | Substituted 3-cyano quinolines | AMERICAN CYANAMID COMPANY | 1999-12-14 | — | — | US | disclosed |