Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 7/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | PLK4 | O00444 | 1/20 | 0.47 |
| ▸ | AURKA | O14965 | 1/20 | 0.47 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.47 |
| ▸ | EGFR | P00533 | 1/20 | 0.47 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.47 |
| ▸ | INSR | P06213 | 1/20 | 0.47 |
| ▸ | IGF1R | P08069 | 1/20 | 0.47 |
| ▸ | MET | P08581 | 1/20 | 0.47 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.47 |
| ▸ | CDK4 | P11802 | 1/20 | 0.47 |
| ▸ | SRC | P12931 | 1/20 | 0.47 |
| ▸ | BRAF | P15056 | 1/20 | 0.47 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.47 |
| ▸ | CCND1 | P24385 | 1/20 | 0.47 |
| ▸ | CDK2 | P24941 | 1/20 | 0.47 |
| ▸ | AKT1 | P31749 | 1/20 | 0.47 |
| ▸ | FLT4 | P35916 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3208873 | 0.83 | HRH3 (0.72) | HRH3ALDH1A1LMNACA1CA2 | |
| SCHEMBL13486632 | 0.79 | HRH3 (0.70) | HRH3 | |
| SCHEMBL13486634 | 0.79 | HRH3 (0.79) | HRH3 | |
| SCHEMBL27944339 | 0.77 | PLK4 (0.55) | ALDH1A1LMNAPLK4AURKANUAK1 | |
| SCHEMBL3198787 | 0.77 | HRH3 (1.00) | HRH3 | |
| SCHEMBL3208630 | 0.77 | HRH3 (0.69) | HRH3LMNA | |
| SCHEMBL29210589 | 0.76 | KDM4E (0.73) | ALDH1A1LMNAPLK4AURKANUAK1 | |
| SCHEMBL30983754 | 0.76 | KDM4E (0.73) | ALDH1A1LMNAPLK4AURKANUAK1 | |
| SCHEMBL3202814 | 0.76 | HRH3 (1.00) | HRH3 | |
| SCHEMBL3200646 | 0.76 | HPGD (0.66) | HRH3ALDH1A1LMNAPLK4AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100035929-A1 | UNNATURAL DISPYRIN ANALOGUES, PREPARATION AND USES THEREOF | VANDERBILT UNIVERSITY | 2010-02-11 | — | — | US | disclosed |
| US-20100035929-A1 | UNNATURAL DISPYRIN ANALOGUES, PREPARATION AND USES THEREOF | VANDERBILT UNIVERSITY | 2010-02-11 | — | — | US | disclosed |
| US-20100035929-A1 | UNNATURAL DISPYRIN ANALOGUES, PREPARATION AND USES THEREOF | VANDERBILT UNIVERSITY | 2010-02-11 | — | — | US | disclosed |
| WO-2009152071-A1 | UNNATURAL DISPYRIN ANALOGUES, PREPARATION AND USES THEREOF | VANDERBILT UNIVERSITY (US) | 2009-12-17 | — | — | WO | disclosed |
| WO-2009152071-A1 | UNNATURAL DISPYRIN ANALOGUES, PREPARATION AND USES THEREOF | VANDERBILT UNIVERSITY (US) | 2009-12-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100035929-A1 | UNNATURAL DISPYRIN ANALOGUES, PREPARATION AND USES THEREOF | HRH3, HRH4, HRH1 | HRH3 1/4885ALDH1A1 1454/4885LMNA 4724/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.