Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 7/20 | 0.40 |
| ▸ | ESR2 | Q92731 | 7/20 | 0.40 |
| ▸ | MIF | P14174 | 2/20 | 0.40 |
| ▸ | ESRRB | O95718 | 4/20 | 0.37 |
| ▸ | ESRRA | P11474 | 4/20 | 0.37 |
| ▸ | MAOA | P21397 | 2/20 | 0.37 |
| ▸ | MAOB | P27338 | 2/20 | 0.37 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.34 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.34 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.32 |
| ▸ | WEE1 | P30291 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3186772 | 0.93 | ESR1 (0.39) | ESR1ESR2MIFESRRBESRRA | |
| SCHEMBL3190566 | 0.89 | ESRRB (0.47) | ESR1ESR2MIFESRRBESRRA | |
| SCHEMBL3179861 | 0.88 | ESR1 (0.40) | ESR1ESR2MIFESRRBESRRA | |
| SCHEMBL3185517 | 0.88 | ESR1 (0.40) | ESR1ESR2MIFESRRBESRRA | |
| SCHEMBL3188483 | 0.88 | ALOX5 (0.39) | ESR1ESR2MIFESRRBESRRA | |
| SCHEMBL3195435 | 0.88 | ESRRB (0.39) | ESR1ESR2MIFESRRBESRRA | |
| SCHEMBL3190395 | 0.87 | GPR84 (0.38) | ESR1ESR2ESRRBESRRAGPR84 | |
| SCHEMBL3197921 | 0.87 | ESR1 (0.36) | ESR1ESR2ESRRBESRRANPC1 | |
| SCHEMBL3178841 | 0.87 | ESRRB (0.49) | ESR1ESR2MIFESRRBESRRA | |
| SCHEMBL3186259 | 0.87 | ESRRB (0.38) | ESR1ESR2ESRRBESRRAMAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7157492-B2 | Dibenzo chromene derivatives and their use as ERβ selective ligands | WYETH (US) | 2007-01-02 | — | — | US | claimed |
| EP-1718630-A1 | DIBENZO CHROMENE DERIVATIVES AND THEIR USE AS ER&bgr; SELECTIVE LIGANDS | Wyeth a Corporation of the State of Delaware (US) | 2006-11-08 | — | — | EP | claimed |
| US-20050234074-A1 | Dibenzo chromene derivatives and their use as ERbeta selective ligands | WYETH (US) | 2005-10-20 | — | — | US | claimed |
| WO-2005082880-A1 | DIBENZO CHROMENE DERIVATIVES AND THEIR USE AS ERβ SELECTIVE LIGANDS | WYETH (US) | 2005-09-09 | — | — | WO | claimed |
| US-7671084-B2 | Dibenzo chromene derivatives and their use as ERβ selective ligands | WYETH (US) | 2010-03-02 | — | — | US | disclosed |
| US-20070049605-A1 | Dibenzo chromene derivatives and their use as ERbeta selective ligands | WYETH (US) | 2007-03-01 | — | — | US | disclosed |
| US-7157492-B2 | Dibenzo chromene derivatives and their use as ERβ selective ligands | WYETH (US) | 2007-01-02 | — | — | US | disclosed |
| US-20050234074-A1 | Dibenzo chromene derivatives and their use as ERbeta selective ligands | WYETH (US) | 2005-10-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050234074-A1 | Dibenzo chromene derivatives and their use as ERbeta selective ligands | ESR2, ESR1, ESRRB | ESR1 2/4885ESR2 1/4885MIF 3907/4885 |
| US-20070049605-A1 | Dibenzo chromene derivatives and their use as ERbeta selective ligands | ESR2, ESR1, ESRRA | ESR1 2/4885ESR2 1/4885MIF 3934/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.