Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 4/20 | 0.40 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.33 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.33 |
| ▸ | QPCT | Q16769 | 4/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.32 |
| ▸ | PDE4A | P27815 | 4/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.31 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3214297 | 0.90 | PDE4B (0.42) | PDE4BGRIN1GRIN2BPDE4APDE4C | |
| SCHEMBL3217097 | 0.84 | HRH4 (0.34) | SLC6A4SLC6A2SLC6A3KMT2A | |
| SCHEMBL3133720 | 0.82 | PDE4A (0.41) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL3129299 | 0.82 | PDE4B (0.41) | PDE4BGRIN1GRIN2BSLC6A4PDE4A | |
| SCHEMBL3133729 | 0.82 | PDE4B (0.38) | PDE4BGRIN1GRIN2BPDE4AKMT2A | |
| SCHEMBL3129586 | 0.81 | PDE4A (0.45) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL3128465 | 0.80 | PDE4A (0.44) | PDE4BGRIN1GRIN2BPDE4APDE4C | |
| SCHEMBL3122554 | 0.80 | PDE4B (0.44) | PDE4B | |
| SCHEMBL3131213 | 0.79 | RXRA (0.50) | PDE4BPDE4AKMT2APDE4CPDE4D | |
| SCHEMBL3120270 | 0.78 | PDE4A (0.38) | PDE4BPDE4AKMT2APDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100029689-A1 | PHOSPHODIESTERASE 4 INHIBITORS | MEMORY PHARMACEUTICALS CORPORATION (US) | 2010-02-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100029689-A1 | PHOSPHODIESTERASE 4 INHIBITORS | PDE4A, PDE4B, PDE3B | PDE4B 2/4885GRIN1 3644/4885GRIN2B 3553/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.