Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.62 |
| ▸ | GPR3 | P46089 | 2/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 12/20 | 0.40 |
| ▸ | ACHE | P22303 | 5/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoromethanesulfonic Acid SCHEMBL31105615 | 1.00 | HDAC8 (0.62) | HDAC8GPR3KCNH2ACHE | |
| Trifluoromethanesulfonic Acid SCHEMBL6421880 | 0.81 | GPR3 (0.43) | GPR3KCNH2ACHE | |
| Trifluoromethanesulfonic Acid SCHEMBL4469432 | 0.81 | GPR3 (0.43) | GPR3KCNH2ACHE | |
| Trifluoromethanesulfonic Acid SCHEMBL30330386 | 0.81 | GPR3 (0.43) | GPR3KCNH2ACHE | |
| Trifluoromethanesulfonic Acid SCHEMBL4476327 | 0.79 | GPR3 (0.42) | GPR3KCNH2ACHE | |
| SCHEMBL9848158 | 0.79 | — | — | |
| Trifluoromethanesulfonic Acid SCHEMBL6517844 | 0.77 | KCNH2 (0.51) | GPR3KCNH2ACHE | |
| Iodide SCHEMBL119846 | 0.77 | — | — | |
| Bromide SCHEMBL9387001 | 0.77 | — | — | |
| Iodide SCHEMBL30213860 | 0.77 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250059187-A1 | COVALENTLY BINDING INHIBITORS OF G12S, G12D AND/OR G12E MUTANTS OF K-RAS GTPASE | UNIV CALIFORNIA (US) | 2025-02-20 | — | — | US | disclosed |
| EP-4452416-A1 | COVALENTLY BINDING INHIBITORS OF G12S, G12D AND/OR G12E MUTANTS OF K-RAS GTPASE | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2024-10-30 | — | — | EP | disclosed |
| WO-2023122662-A1 | COVALENTLY BINDING INHIBITORS OF G12S, G12D AND/OR G12E MUTANTS OF K-RAS GTPASE | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2023-06-29 | — | — | WO | disclosed |
| US-20140073778-A9 | CONJUGATES COMPRISING HYDROXYALKYL STARCH AND A CYTOTOXIC AGENT AND PROCESS FOR THEIR PREPARATION | FRESENIUS KABI DEUTSCHLAND GMBH (DE) | 2014-03-13 | — | — | US | disclosed |
| US-20130184454-A1 | CONJUGATES COMPRISING HYDROXYALKYL STARCH AND A CYTOTOXIC AGENT AND PROCESS FOR THEIR PREPARATION | FRESENIUS KABI DEUTSCHLAND GMBH (DE) | 2013-07-18 | — | — | US | disclosed |
| EP-2591008-A1 | CONJUGATES COMPRISING HYDROXYALKYL STARCH AND A CYTOTOXIC AGENT AND PROCESS FOR THEIR PREPARATION | Fresenius Kabi Deutschland GmbH (DE) | 2013-05-15 | — | — | EP | disclosed |
| WO-2012004008-A1 | CONJUGATES COMPRISING HYDROXYALKYL STARCH AND A CYTOTOXIC AGENT AND PROCESS FOR THEIR PREPARATION | FRESENIUS KABI DEUTSCHLAND GMBH (DE) | 2012-01-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250059187-A1 | COVALENTLY BINDING INHIBITORS OF G12S, G12D AND/OR G12E MUTANTS OF K-RAS GTPASE | KRAS, HRAS, NRAS | HDAC8 1696/4885GPR3 2592/4885KCNH2 3704/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.