Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.67 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.61 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.61 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.61 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.56 |
| ▸ | MEN1 | O00255 | 4/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 4/20 | 0.56 |
| ▸ | NPC1 | O15118 | 3/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.56 |
| ▸ | MDH1 | P40925 | 2/20 | 0.56 |
| ▸ | MDH2 | P40926 | 2/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | PLAU | P00749 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL321393 | 0.88 | SMN1; SMN2 (0.61) | MAPTKDM4ECYP1A2CYP3A4CYP2C9 | |
| SCHEMBL321736 | 0.88 | KMT2A (0.58) | MAPTCYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL3898629 | 0.87 | CYP1A2 (0.59) | MAPTKDM4ECYP1A2CYP3A4CYP2C9 | |
| SCHEMBL3900523 | 0.81 | L3MBTL1 (0.57) | MAPTCYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL25196508 | 0.78 | SMPD1 (0.73) | KMT2AMEN1RAB9ASMN1; SMN2 | |
| SCHEMBL321291 | 0.78 | ALDH1A1 (0.63) | MAPTCYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL320847 | 0.77 | KMT2A (0.55) | ALDH1A1KMT2AMEN1POLBRAB9A | |
| SCHEMBL320474 | 0.77 | KMT2A (0.55) | ALDH1A1KMT2AMEN1POLBRAB9A | |
| SCHEMBL320697 | 0.76 | KMT2A (0.60) | MAPTKMT2AMEN1RAB9ANPC1 | |
| SCHEMBL320846 | 0.76 | ALDH1A1 (0.59) | MAPTKDM4ECYP1A2CYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2590942-A1 | RHO KINASE INHIBITORS | Boehringer Ingelheim International GmbH (DE) | 2013-05-15 | — | — | EP | disclosed |
| WO-2012006202-A1 | RHO KINASE INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-01-12 | — | — | WO | disclosed |