Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 16/20 | 0.50 |
| ▸ | GPR183 | P32249 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.43 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3206474 | 0.92 | GPR119 (0.49) | GPR119GPR183KCNH2CHRM4NPC1 | |
| SCHEMBL2404798 | 0.89 | GPR119 (0.47) | GPR119GPR183KCNH2NPC1RAB9A | |
| SCHEMBL1834757 | 0.88 | GPR119 (0.50) | GPR119GPR183KCNH2CHRM4NPC1 | |
| SCHEMBL1922600 | 0.86 | GPR119 (0.52) | GPR119GPR183KCNH2CHRM4 | |
| SCHEMBL3209837 | 0.86 | GPR119 (0.53) | GPR119GPR183KCNH2 | |
| SCHEMBL2247183 | 0.84 | GPR119 (0.49) | GPR119GPR183KCNH2CHRM4NPC1 | |
| SCHEMBL3218225 | 0.83 | GPR119 (0.47) | GPR119GPR183KCNH2 | |
| SCHEMBL1922888 | 0.83 | GPR119 (0.52) | GPR119GPR183KCNH2 | |
| SCHEMBL2566410 | 0.83 | GPR119 (0.58) | GPR119GPR183KCNH2 | |
| SCHEMBL1713336 | 0.82 | GPR119 (0.46) | GPR119GPR183KCNH2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130109703-A1 | Combination of a GPR119 Agonist and the DPP-IV Inhibitor Linagliptin for Use in the Treatment of Diabetes and Related Conditions | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2013-05-02 | — | — | US | claimed |
| EP-2547339-A1 | COMBINATION OF A GPR119 AGONIST AND THE DPP-IV INHIBITOR LINAGLIPTIN FOR USE IN THE TREATMENT OF DIABETES AND RELATED CONDITIONS | Boehringer Ingelheim International GmbH (DE) | 2013-01-23 | — | — | EP | claimed |
| US-20130109703-A1 | Combination of a GPR119 Agonist and the DPP-IV Inhibitor Linagliptin for Use in the Treatment of Diabetes and Related Conditions | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2013-05-02 | — | — | US | disclosed |
| EP-2547339-A1 | COMBINATION OF A GPR119 AGONIST AND THE DPP-IV INHIBITOR LINAGLIPTIN FOR USE IN THE TREATMENT OF DIABETES AND RELATED CONDITIONS | Boehringer Ingelheim International GmbH (DE) | 2013-01-23 | — | — | EP | disclosed |
| US-20100048625-A1 | PIPERIDINE GPCR AGONISTS | PROSIDION LIMITED (GB) | 2010-02-25 | — | — | US | disclosed |
| US-20100048625-A1 | PIPERIDINE GPCR AGONISTS | PROSIDION LIMITED (GB) | 2010-02-25 | — | — | US | disclosed |
| US-20100048625-A1 | PIPERIDINE GPCR AGONISTS | PROSIDION LIMITED (GB) | 2010-02-25 | — | — | US | disclosed |
| EP-2114936-A1 | PIPERIDINE GPCR AGONISTS | Prosidion Limited (GB) | 2009-11-11 | — | — | EP | disclosed |
| WO-2008081208-A1 | PIPERIDINE GPCR AGONISTS | PROSIDION LIMITED (GB) | 2008-07-10 | — | — | WO | disclosed |
| WO-2008081208-A1 | PIPERIDINE GPCR AGONISTS | PROSIDION LIMITED (GB) | 2008-07-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100048625-A1 | PIPERIDINE GPCR AGONISTS | GPR119, GPR27, GLP1R | GPR119 1/4885GPR183 45/4885KCNH2 1128/4885 |
| US-20130109703-A1 | Combination of a GPR119 Agonist and the DPP-IV Inhibitor Linagliptin for Use in the Treatment of Diabetes and Related Conditions | GPR119, DPP4, GLP1R | GPR119 1/4885GPR183 62/4885KCNH2 3673/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.