Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4A | O75164 | 1/20 | 0.49 |
| ▸ | KDM5A | P29375 | 1/20 | 0.49 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.49 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | CDK5 | Q00535 | 4/20 | 0.36 |
| ▸ | CDK5R1 | Q15078 | 4/20 | 0.36 |
| ▸ | BCHE | P06276 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3201410 | 0.91 | KDM4A (0.42) | KDM4AKDM5AKDM4CKDM5BMEN1 | |
| SCHEMBL3198003 | 0.85 | KDM4A (0.46) | KDM4AKDM5AKDM4CKDM5BMEN1 | |
| SCHEMBL28935063 | 0.82 | KDM5A (0.46) | KDM5AMEN1KMT2ACDK5CDK5R1 | |
| SCHEMBL13406325 | 0.76 | PLAT (0.45) | KDM5AMEN1KMT2ACDK5CDK5R1 | |
| SCHEMBL23451266 | 0.75 | CDK5 (0.49) | KDM4AKDM5AKDM4CKDM5BMEN1 | |
| SCHEMBL21063662 | 0.74 | GPR119 (0.43) | KDM5AJAK2ALDH1A1NAMPT | |
| SCHEMBL8550973 | 0.72 | GPR119 (0.51) | JAK2ALDH1A1 | |
| SCHEMBL3190003 | 0.69 | MAPK1 (0.47) | BCHEMAPK1RAB9ASLC6A4SLC6A3 | |
| SCHEMBL13486172 | 0.69 | KDM4A (0.48) | KDM4AKDM5AKDM4CKDM5BCDK5 | |
| SCHEMBL71789 | 0.69 | MEN1 (0.59) | MEN1KMT2AALDH1A1LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100041722-A1 | ORGANIC COMPOUNDS | HU QI-YING | 2010-02-18 | — | — | US | disclosed |
| US-20100041722-A1 | ORGANIC COMPOUNDS | HU QI-YING | 2010-02-18 | — | — | US | disclosed |
| EP-2094669-A2 | 1-SUBSTITUTED IMIDAZOLE DERIVATIVES AND THEIR USE AS ALDOSTERONE SYNTHASE INHIBITORS | Novartis AG (CH) | 2009-09-02 | — | — | EP | disclosed |
| WO-2008076862-A2 | 1-SUBSTITUTED IMIDAZOLE DERIVATIVES AND THEIR USE AS ALDOSTERONE SYNTHASE INHIBITORS | NOVARTIS AG (CH) | 2008-06-26 | — | — | WO | disclosed |
| WO-2008076862-A2 | 1-SUBSTITUTED IMIDAZOLE DERIVATIVES AND THEIR USE AS ALDOSTERONE SYNTHASE INHIBITORS | NOVARTIS AG (CH) | 2008-06-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100041722-A1 | ORGANIC COMPOUNDS | CYP11B1, CYP11B2, CYP21A2 | KDM4A 2449/4885KDM5A 1613/4885KDM4C 2675/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.