Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 6/20 | 0.65 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.59 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.56 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.56 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.53 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | FUCA1 | P04066 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | ACHE | P22303 | 1/20 | 0.49 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.48 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3206279 | 1.00 | GRIN2B (0.65) | GRIN2BTAAR1ALDH1A1OPRM1OPRL1 | |
| SCHEMBL662411 | 0.91 | GRIN2B (0.76) | GRIN2BTAAR1OPRM1OPRL1GRIN1 | |
| SCHEMBL14117439 | 0.90 | GRIN2B (0.67) | GRIN2BALDH1A1OPRM1OPRL1GRIN1 | |
| SCHEMBL2661158 | 0.88 | GRIN2B (0.68) | GRIN2BALDH1A1OPRM1OPRL1GRIN1 | |
| SCHEMBL2661157 | 0.88 | GRIN2B (0.68) | GRIN2BALDH1A1OPRM1OPRL1GRIN1 | |
| SCHEMBL10031636 | 0.84 | GRIN2B (0.61) | GRIN2BTAAR1OPRM1OPRL1GRIN1 | |
| SCHEMBL3907332 | 0.83 | TAAR1 (0.81) | GRIN2BTAAR1ALDH1A1OPRM1OPRL1 | |
| SCHEMBL3760581 | 0.83 | TAAR1 (0.75) | GRIN2BTAAR1OPRM1OPRL1GRIN1 | |
| SCHEMBL16480070 | 0.83 | ALDH1A1 (0.52) | GRIN2BTAAR1ALDH1A1OPRM1OPRL1 | |
| SCHEMBL14934759 | 0.82 | GRIN2B (0.65) | GRIN2BTAAR1ALDH1A1OPRM1OPRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8362049-B2 | Urea glucokinase activators | NOVO NORDISK A/S (DK) | 2013-01-29 | — | — | US | disclosed |
| US-8318778-B2 | Urea glucokinase activators | NOVO NORDISK A/S (DK) | 2012-11-27 | — | — | US | disclosed |
| US-20120165375-A1 | Urea Glucokinase Activators | NOVO NORDISK A/S (DK) | 2012-06-28 | — | — | US | disclosed |
| US-20100041711-A1 | Urea Glucokinase Activators | NOVO NORDISK A/S (DK) | 2010-02-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100041711-A1 | Urea Glucokinase Activators | GCK, GCKR, HK2 | GRIN2B 4168/4885TAAR1 4715/4885ALDH1A1 2703/4885 |
| US-20120165375-A1 | Urea Glucokinase Activators | GCK, GCKR, HK2 | GRIN2B 4168/4885TAAR1 4715/4885ALDH1A1 2703/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.