Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR5 | Q9H228 | 9/20 | 0.49 |
| ▸ | EGFR | P00533 | 3/20 | 0.42 |
| ▸ | S1PR1 | P21453 | 3/20 | 0.41 |
| ▸ | S1PR3 | Q99500 | 3/20 | 0.41 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15139921 | 0.87 | S1PR5 (0.51) | S1PR5S1PR1S1PR3 | |
| SCHEMBL325350 | 0.84 | DRD2 (0.41) | S1PR5S1PR1S1PR3 | |
| SCHEMBL15144608 | 0.81 | S1PR5 (0.54) | S1PR5EGFRS1PR1S1PR3HRH3 | |
| SCHEMBL326290 | 0.80 | S1PR5 (0.78) | S1PR5S1PR1S1PR3 | |
| SCHEMBL15144611 | 0.77 | S1PR5 (0.70) | S1PR5S1PR1S1PR3 | |
| SCHEMBL21326840 | 0.75 | HRH3 (0.45) | S1PR5EGFRHRH3 | |
| SCHEMBL1979306 | 0.74 | YAP1 (0.49) | — | |
| SCHEMBL15144634 | 0.74 | S1PR5 (0.63) | S1PR5S1PR1S1PR3 | |
| SCHEMBL15144594 | 0.74 | S1PR5 (0.44) | S1PR5EGFRHRH3 | |
| SCHEMBL321366 | 0.73 | KDM1A (0.43) | LMNAHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2590955-A1 | SPIRO-CYCLIC AMINE DERIVATIVES AS S1P MODULATORS | ABBVIE B.V. (NL) | 2013-05-15 | — | — | EP | disclosed |
| WO-2012004378-A1 | SPIRO-CYCLIC AMINE DERIVATIVES AS S1P MODULATORS | ABBOTT HEALTHCARE PRODUCTS B.V. (NL) | 2012-01-12 | — | — | WO | disclosed |