Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.49 |
| ▸ | ASPH | Q12797 | 3/20 | 0.49 |
| ▸ | KDM8 | Q8N371 | 2/20 | 0.49 |
| ▸ | KMO | O15229 | 3/20 | 0.46 |
| ▸ | CASP3 | P42574 | 2/20 | 0.45 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.45 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.45 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.45 |
| ▸ | P4HTM | Q9NXG6 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.42 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | APEX1 | P27695 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL3207242 | 0.98 | KDM4E (0.47) | KDM4EASPHKDM8KMOCASP3 | |
| SCHEMBL12035783 | 0.93 | KDM4E (0.49) | KDM4EASPHKDM8KMOP4HTM | |
| Hydrochloric Acid SCHEMBL1503769 | 0.91 | KDM4E (0.47) | KDM4EASPHKDM8KMOP4HTM | |
| SCHEMBL209902 | 0.80 | ABL1 (0.44) | CASP3SENP8SENP7SENP6ALDH1A1 | |
| SCHEMBL212757 | 0.80 | LCK (0.55) | KDM4ECASP3SENP8SENP7SENP6 | |
| SCHEMBL30481293 | 0.79 | KDM4E (0.56) | KDM4EASPHKDM8P4HTMALDH1A1 | |
| SCHEMBL6101082 | 0.79 | KMO (0.46) | KDM4EASPHKDM8KMOP4HTM | |
| SCHEMBL14684656 | 0.79 | KDM4E (0.56) | KDM4EASPHKDM8P4HTMALDH1A1 | |
| SCHEMBL6099196 | 0.79 | CYP2A6 (0.45) | KDM4EASPHKDM8KMOP4HTM | |
| SCHEMBL31055620 | 0.78 | KDM4E (0.50) | KDM4EASPHKDM8KMOP4HTM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1633752-B1 | ISOQUINOLINE-3-CARBOXYLIC ACID AMIDES AND PHARMACEUTICAL USES THEREOF | NOVARTIS AG (CH) | 2010-10-06 | — | — | EP | claimed |
| US-20070142428-A1 | Isoquinoline-3-carboxylic acid amides and pharmaceutical uses thereof | NOVARTIS AG (CH) | 2007-06-21 | — | — | US | claimed |
| EP-1633752-B1 | ISOQUINOLINE-3-CARBOXYLIC ACID AMIDES AND PHARMACEUTICAL USES THEREOF | NOVARTIS AG (CH) | 2010-10-06 | — | — | EP | disclosed |
| US-7683075-B2 | Isoquinoline-3-carboxylic acid amides and pharmaceutical uses thereof | NOVARTIS AG (CH) | 2010-03-23 | — | — | US | disclosed |
| CN-100341874-C | Isoquinoline-3-carboxylic acid amides and pharmaceutical uses thereof | NOVARTIS AG (CH) | 2007-10-10 | — | — | CN | disclosed |
| US-20070142428-A1 | Isoquinoline-3-carboxylic acid amides and pharmaceutical uses thereof | NOVARTIS AG (CH) | 2007-06-21 | — | — | US | disclosed |
| CN-1784404-A | Isoquinoline-3-carboxylic acid amides and pharmaceutical uses thereof | NOVARTIS AG (CH) | 2006-06-07 | — | — | CN | disclosed |
| EP-1633752-A1 | ISOQUINOLINE-3-CARBOXYLIC ACID AMIDES AND PHARMACEUTICAL USES THEREOF | Novartis AG (CH) | 2006-03-15 | — | — | EP | disclosed |
| WO-2004099206-A1 | ISOQUINOLINE-3-CARBOXYLIC ACID AMIDES AND PHARMACEUTICAL USES THEREOF | NOVARTIS AG (CH) | 2004-11-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070142428-A1 | Isoquinoline-3-carboxylic acid amides and pharmaceutical uses thereof | CHRNA7, CHRNA3, CHRNA1 | KDM4E 2996/4885ASPH 1588/4885KDM8 2011/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.