Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.52 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.48 |
| ▸ | FOS | P01100 | 1/20 | 0.47 |
| ▸ | JUN | P05412 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | TGM2 | P21980 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 3/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | PKM | P14618 | 2/20 | 0.43 |
| ▸ | ATM | Q13315 | 2/20 | 0.43 |
| ▸ | NLRP1 | Q9C000 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetic Acid SCHEMBL28854711 | 0.93 | ALDH1A1 (0.50) | ALDH1A1CYP2A6FOSJUNSMN1; SMN2 | |
| Acrylic Acid SCHEMBL80864 | 0.91 | ALDH1A1 (0.48) | ALDH1A1CYP2A6FOSJUNSMN1; SMN2 | |
| Maleic Acid SCHEMBL8864871 | 0.89 | ALDH1A1 (0.57) | ALDH1A1CYP2A6FOSJUNSMN1; SMN2 | |
| Benzene SCHEMBL28408287 | 0.87 | ALDH1A1 (0.61) | ALDH1A1CYP2A6SMN1; SMN2TSHRMAPT | |
| Methacrylic Acid SCHEMBL5788718 | 0.87 | CYP3A4 (0.46) | ALDH1A1CYP2A6FOSJUNSMN1; SMN2 | |
| SCHEMBL14911 | 0.87 | — | — | |
| SCHEMBL679555 | 0.87 | ALDH1A1 (0.69) | ALDH1A1CYP2A6SMN1; SMN2TSHRMAPT | |
| Formic Acid SCHEMBL8861832 | 0.86 | CYP2A6 (0.54) | ALDH1A1CYP2A6FOSJUNSMN1; SMN2 | |
| Ethane SCHEMBL23051531 | 0.85 | ALDH1A1 (0.65) | ALDH1A1CYP2A6SMN1; SMN2TSHRMAPT | |
| Ethylene SCHEMBL10713150 | 0.85 | ALDH1A1 (0.65) | ALDH1A1CYP2A6SMN1; SMN2TSHRMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100036137-A1 | PROCESS FOR THE PREPARATION OF ALKYLENE CARBONATES | MCGILL UNIVERSITY (CA) | 2010-02-11 | — | — | US | disclosed |
| WO-2008034265-A1 | PROCESS FOR THE PREPARATION OF ALKYLENE CARBONATES | MCGILL UNIVERSITY (CA) | 2008-03-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100036137-A1 | PROCESS FOR THE PREPARATION OF ALKYLENE CARBONATES | SCO2, CYP11B2, CBR1 | ALDH1A1 3289/4885CYP2A6 794/4885FOS 810/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.