Sugi Predict

Sugi Predict / Compounds / SCHEMBL3209610

SCHEMBL3209610

SCHEMBL3209610

COc1cc(N(Cc2cnco2)c2ccc(C(=O)O)cc2)ccc1OCC(F)(F)F

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ RXRA P19793 4/20 0.46
▸ TSHR P16473 1/20 0.38
▸ AAK1 Q2M2I8 1/20 0.38
▸ L3MBTL1 Q9Y468 1/20 0.38
▸ HNF4A P41235 1/20 0.37
▸ MCHR1 Q99705 1/20 0.36
▸ HTT P42858 1/20 0.36
▸ LTC4S Q16873 1/20 0.35
▸ RXRB P28702 2/20 0.35
▸ RXRG P48443 2/20 0.35
▸ CA12 O43570 1/20 0.35
▸ CA1 P00915 1/20 0.35
▸ CA2 P00918 1/20 0.35
▸ CA4 P22748 1/20 0.35
▸ CA6 P23280 1/20 0.35
▸ CA7 P43166 1/20 0.35
▸ TPMT P51580 1/20 0.35
▸ CA9 Q16790 1/20 0.35
▸ CA14 Q9ULX7 1/20 0.35
▸ GPR119 Q8TDV5 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3214119 0.89 GPR119 (0.40) RXRAAAK1MCHR1LTC4SGPR119
SCHEMBL3200044 0.89 TSHR (0.52) RXRATSHRAAK1L3MBTL1MCHR1
SCHEMBL3205215 0.87 AAK1 (0.37) RXRAAAK1HTTRXRBRXRG
SCHEMBL3129582 0.86 RXRA (0.48) RXRATSHRL3MBTL1HNF4AMCHR1
SCHEMBL3129423 0.85 POLB (0.41) RXRATSHRAAK1HTTRXRB
SCHEMBL3192998 0.85 TSHR (0.46) RXRATSHRAAK1L3MBTL1RXRB
SCHEMBL3122854 0.83 HTT (0.39) RXRATSHRAAK1HTTRXRB
SCHEMBL3202322 0.83 RXRA (0.43) RXRATSHRL3MBTL1LTC4SRXRB
SCHEMBL3215184 0.82 RXRA (0.49) RXRAAAK1RXRBRXRGCA12
SCHEMBL3213430 0.81 RXRA (0.40) RXRATSHRAAK1L3MBTL1RXRB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20100029689-A1 PHOSPHODIESTERASE 4 INHIBITORS MEMORY PHARMACEUTICALS CORPORATION (US) 2010-02-04 — — US claimed
WO-2010003084-A2 PHOSPHODIESTERASE 4 INHIBITORS MEMORY PHARMACEUTICALS CORPORATION (US) 2010-01-07 — — WO claimed
US-20100029689-A1 PHOSPHODIESTERASE 4 INHIBITORS MEMORY PHARMACEUTICALS CORPORATION (US) 2010-02-04 — — US disclosed
US-20100029689-A1 PHOSPHODIESTERASE 4 INHIBITORS MEMORY PHARMACEUTICALS CORPORATION (US) 2010-02-04 — — US disclosed
US-20100029689-A1 PHOSPHODIESTERASE 4 INHIBITORS MEMORY PHARMACEUTICALS CORPORATION (US) 2010-02-04 — — US disclosed
WO-2010003084-A2 PHOSPHODIESTERASE 4 INHIBITORS MEMORY PHARMACEUTICALS CORPORATION (US) 2010-01-07 — — WO disclosed
WO-2010003084-A2 PHOSPHODIESTERASE 4 INHIBITORS MEMORY PHARMACEUTICALS CORPORATION (US) 2010-01-07 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100029689-A1 PHOSPHODIESTERASE 4 INHIBITORS PDE4A, PDE4B, PDE3B RXRA 2856/4885TSHR 1908/4885AAK1 2805/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.