Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NUDT1 | P36639 | 1/20 | 0.53 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.50 |
| ▸ | FLT1 | P17948 | 2/20 | 0.50 |
| ▸ | PARP1 | P09874 | 3/20 | 0.49 |
| ▸ | METAP1 | P53582 | 2/20 | 0.47 |
| ▸ | METAP2 | P50579 | 1/20 | 0.47 |
| ▸ | AURKA | O14965 | 3/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | PDE5A | O76074 | 2/20 | 0.44 |
| ▸ | DAO | P14920 | 1/20 | 0.44 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | PDE2A | O00408 | 1/20 | 0.42 |
| ▸ | PDE6D | O43924 | 1/20 | 0.42 |
| ▸ | PDE8A | O60658 | 1/20 | 0.42 |
| ▸ | PDE9A | O76083 | 1/20 | 0.42 |
| ▸ | PDE8B | O95263 | 1/20 | 0.42 |
| ▸ | PDE6A | P16499 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1133963 | 0.79 | NUDT1 (0.62) | NUDT1FGFR1FLT1PARP1METAP1 | |
| SCHEMBL939186 | 0.79 | NUDT1 (0.53) | NUDT1FGFR1FLT1PARP1METAP1 | |
| SCHEMBL14765145 | 0.79 | NUDT1 (0.53) | NUDT1FGFR1FLT1PARP1METAP1 | |
| SCHEMBL1427745 | 0.77 | NUDT1 (0.60) | NUDT1METAP1METAP2AURKATP53 | |
| SCHEMBL10375895 | 0.75 | NUDT1 (0.49) | NUDT1FGFR1FLT1PARP1METAP1 | |
| SCHEMBL18726171 | 0.73 | FGFR1 (0.65) | FGFR1FLT1METAP1METAP2AURKA | |
| SCHEMBL323981 | 0.73 | NUDT1 (0.60) | NUDT1FGFR1FLT1METAP1METAP2 | |
| SCHEMBL7456831 | 0.73 | PSMB8 (0.53) | NUDT1FGFR1FLT1PARP1AURKA | |
| SCHEMBL1170747 | 0.72 | METAP1 (0.72) | NUDT1FGFR1FLT1METAP1METAP2 | |
| SCHEMBL853992 | 0.72 | PLAUR (0.61) | FGFR1TP53SMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010008775-A1 | AMINOPYRIDOPYRAZINONE DERIVATIVES FOR TREATING NEURODEGENERATIVE DISEASES | LIGAND PHARMACEUTICALS INC. (US) | 2010-01-21 | — | — | WO | disclosed |