Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | XBP1 | P17861 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10882925 | 0.72 | LMNA (0.35) | NPC1ALDH1A1TP53MAPTXBP1 | |
| SCHEMBL12970649 | 0.72 | — | — | |
| SCHEMBL3221058 | 0.70 | KMT2A (0.37) | — | |
| SCHEMBL3214580 | 0.69 | MAP4K4 (0.31) | — | |
| SCHEMBL1490115 | 0.67 | IRAK4 (0.38) | NPC1ALDH1A1TP53MAPTXBP1 | |
| SCHEMBL29472080 | 0.67 | IRAK4 (0.38) | NPC1ALDH1A1TP53MAPTXBP1 | |
| SCHEMBL12970617 | 0.67 | MYC (0.30) | — | |
| SCHEMBL31461745 | 0.66 | TP53 (0.49) | NPC1ALDH1A1TP53MAPTXBP1 | |
| SCHEMBL13736275 | 0.64 | NNMT (0.44) | NPC1ALDH1A1TP53MAPTXBP1 | |
| SCHEMBL15286672 | 0.64 | MAPT (0.62) | NPC1ALDH1A1TP53MAPTXBP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7683097-B2 | Topoisomerase inhibitors | Propharmacon Inc. (US) | 2010-03-23 | — | — | US | claimed |
| WO-2006022955-A2 | TOPOISOMERASE INHIBITORS | PROPHARMACON, INC. (US) | 2006-03-02 | — | — | WO | disclosed |