Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 2/20 | 0.73 |
| ▸ | CA2 | P00918 | 2/20 | 0.73 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.72 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.72 |
| ▸ | MAOA | P21397 | 2/20 | 0.72 |
| ▸ | MAOB | P27338 | 2/20 | 0.72 |
| ▸ | BACE1 | P56817 | 9/20 | 0.69 |
| ▸ | MMP9 | P14780 | 3/20 | 0.66 |
| ▸ | APP | P05067 | 5/20 | 0.63 |
| ▸ | MAPT | P10636 | 5/20 | 0.63 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.63 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.63 |
| ▸ | TSHR | P16473 | 2/20 | 0.63 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.63 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.63 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.63 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.63 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.63 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.63 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3211190 | 1.00 | CA1 (0.73) | CA1CA2ABCB1AKR1B1MAOA | |
| SCHEMBL3216853 | 0.93 | NFE2L2 (0.70) | CA1CA2ABCB1AKR1B1MAOA | |
| SCHEMBL3216888 | 0.93 | NFE2L2 (0.70) | CA1CA2ABCB1AKR1B1MAOA | |
| SCHEMBL3211184 | 0.90 | APP (0.80) | CA1CA2ABCB1AKR1B1MAOA | |
| SCHEMBL3211168 | 0.90 | APP (0.80) | CA1CA2ABCB1AKR1B1MAOA | |
| SCHEMBL3213869 | 0.89 | MAPT (0.74) | CA1CA2ABCB1AKR1B1MAOA | |
| SCHEMBL3213847 | 0.89 | MAPT (0.74) | CA1CA2ABCB1AKR1B1MAOA | |
| SCHEMBL3206032 | 0.85 | NFE2L2 (0.85) | CA1CA2ABCB1AKR1B1MAOA | |
| SCHEMBL3206013 | 0.85 | NFE2L2 (0.85) | CA1CA2ABCB1AKR1B1MAOA | |
| SCHEMBL431246 | 0.84 | ABCB1 (1.00) | CA1CA2ABCB1AKR1B1MAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8962674-B2 | Curcumin derivative | TOKYO INSTITUTE OF TECHNOLOGY (JP) | 2015-02-24 | — | — | US | disclosed |
| US-20100048901-A1 | NOVEL CURCUMIN DERIVATIVE | TOKYO INSTITUTE OF TECHNOLOGY (JP) | 2010-02-25 | — | — | US | disclosed |
| EP-2123637-A1 | NOVEL CURCUMIN DERIVATIVE | Tokyo Institute of Technology (JP) | 2009-11-25 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100048901-A1 | NOVEL CURCUMIN DERIVATIVE | BACE1, APP, BACE2 | CA1 271/4885CA2 1240/4885ABCB1 3282/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.