SCHEMBL431246

SCHEMBL431246

COc1cc(/C=C/C(=O)CC(=O)/C=C/c2ccc(O)cc2)ccc1O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ABCB1 P08183 2/20 1.00
AKR1B1 P15121 2/20 1.00
MAOA P21397 2/20 1.00
MAOB P27338 2/20 1.00
BACE1 P56817 8/20 0.89
APP P05067 7/20 0.89
MAPT P10636 7/20 0.89
MMP9 P14780 5/20 0.89
NFKB1 P19838 3/20 0.89
CYP2D6 P10635 2/20 0.89
CYP2C9 P11712 2/20 0.89
TSHR P16473 2/20 0.89
HSD17B10 Q99714 2/20 0.89
HDAC3 O15379 2/20 0.89
HDAC1 Q13547 2/20 0.89
HDAC2 Q92769 2/20 0.89
HDAC6 Q9UBN7 2/20 0.89
ALOX5 P09917 2/20 0.89
STAT3 P40763 2/20 0.89
NFKB2 Q00653 2/20 0.89

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13521973 1.00 ABCB1 (1.00) ABCB1AKR1B1MAOAMAOBBACE1
SCHEMBL21327853 1.00 ABCB1 (1.00) ABCB1AKR1B1MAOAMAOBBACE1
SCHEMBL2553051 1.00 ABCB1 (1.00) ABCB1AKR1B1MAOAMAOBBACE1
Curcumin SCHEMBL28278390 0.99 ABCB1 (0.97) ABCB1AKR1B1MAOAMAOBBACE1
SCHEMBL23176040 0.95 ABCB1 (0.90) ABCB1AKR1B1MAOAMAOBBACE1
Curcumin SCHEMBL2303947 0.95 ABCB1 (0.90) ABCB1AKR1B1MAOAMAOBBACE1
Curcumin SCHEMBL250984 0.94 APP (1.00) ABCB1AKR1B1MAOAMAOBBACE1
Curcumin SCHEMBL2804734 0.94 APP (1.00) ABCB1AKR1B1MAOAMAOBBACE1
Curcumin SCHEMBL8440 0.94 APP (1.00) ABCB1AKR1B1MAOAMAOBBACE1
Curcumin SCHEMBL6901740 0.94 APP (1.00) ABCB1AKR1B1MAOAMAOBBACE1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 306 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240315965-A1 COMPOSITIONS AND METHODS RELATED TO PHARMACEUTICAL EXCIPIENTS Natural Extraction Systems, LLC (US) 2024-09-26 US claimed
US-20240183526-A1 SYSTEMS, DEVICES, AND METHODS FOR A BOILER HEALTH AND CARBON-FOOTPRINT MONITOR TOOL SAUDI ARABIAN OIL COMPANY (SA) 2024-06-06 US claimed
WO-2022182527-A1 COMPOSITIONS AND METHODS RELATED TO PHARMACEUTICAL EXCIPIENTS Natural Extraction Systems, LLC (US) 2022-09-01 WO claimed
CN-105030623-B Maca facial mask 上海悦萌环保科技有限公司 2018-01-23 CN claimed
CN-105078833-B Maca facial mask, pleura and preparation method thereof 广东长昊药业股份有限公司 2017-12-08 CN claimed
US-20160354504-A1 MALODOR COUNTERACTING COMPOSITIONS INTERNATIONAL FLAVORS & FRAGRANCES INC. (US) 2016-12-08 US claimed
EP-3101171-A1 MALODOR COUNTERACTING COMPOSITIONS International Flavors & Fragrances Inc. (US) 2016-12-07 EP claimed
EP-1978984-B1 NUTRITIONAL SYSTEM AND METHODS FOR INCREASING LONGEVITY NESTEC SA (CH) 2015-06-10 EP claimed
US-20130316029-A1 METHODS AND COMPOSITIONS SUITABLE FOR MANAGING BLOOD GLUCOSE IN ANIMALS NESTEC S.A. (CH) 2013-11-28 US claimed
EP-2654777-A2 METHODS AND COMPOSITIONS SUITABLE FOR MANAGING BLOOD GLUCOSE IN ANIMALS Nestec S.A. (CH) 2013-10-30 EP claimed
WO-2012087742-A2 METHODS AND COMPOSITIONS SUITABLE FOR MANAGING BLOOD GLUCOSE IN ANIMALS NESTEC S.A. (CH) 2012-06-28 WO claimed
WO-2012057824-A1 METHODS AND COMPOSITIONS SUITABLE FOR PROMOTING HEALTHY SKIN NESTEC S.A. (CH) 2012-05-03 WO claimed
US-20090000734-A1 Method For Producing a Cladding Element INTERGLARION LIMITED (CY) 2009-01-01 US claimed
EP-1978984-A2 NUTRITIONAL SYSTEM AND METHODS FOR INCREASING LONGEVITY NESTEC S.A. (CH) 2008-10-15 EP claimed
US-20070231371-A1 Nutritional system and methods for increasing longevity NESTEC, S. A. 2007-10-04 US claimed
WO-2007088046-A2 NUTRITIONAL SYSTEM AND METHODS FOR INCREASING LONGEVITY NESTEC S.A. (CH) 2007-08-09 WO claimed
CN-1908300-A Application of curcuma longa in paper and paperboard making HUANG HUAXIN (CN) 2007-02-07 CN claimed
CN-1908085-A Application of curcuma in coating manufacture HUANG HUAXIN (CN) 2007-02-07 CN claimed
CN-1241997-C Purification process for improving total yield of curcuminoid colouring agent HANSENS LAB (DK) 2006-02-15 CN claimed
CN-1447839-A Purification process for improving total yield of curcuminoid colouring agent HANSENS LAB (DK) 2003-10-08 CN claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160354504-A1 MALODOR COUNTERACTING COMPOSITIONS LPO, MAL2, ME1 ABCB1 4411/4885AKR1B1 550/4885MAOA 1117/4885
US-20070231371-A1 Nutritional system and methods for increasing longevity AGER, GCKR, IGFBP1 ABCB1 4883/4885AKR1B1 869/4885MAOA 3101/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.