Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 6/20 | 0.64 |
| ▸ | BCR | P11274 | 5/20 | 0.64 |
| ▸ | LCK | P06239 | 2/20 | 0.61 |
| ▸ | RET | P07949 | 2/20 | 0.53 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.47 |
| ▸ | CDK1 | P06493 | 1/20 | 0.47 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.47 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.47 |
| ▸ | PRKCA | P17252 | 3/20 | 0.47 |
| ▸ | BRD4 | O60885 | 1/20 | 0.46 |
| ▸ | CDK2 | P24941 | 1/20 | 0.46 |
| ▸ | CDK9 | P50750 | 1/20 | 0.46 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.44 |
| ▸ | GSK3B | P49841 | 1/20 | 0.44 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.44 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.44 |
| ▸ | PDGFRB | P09619 | 4/20 | 0.44 |
| ▸ | PDGFRA | P16234 | 4/20 | 0.44 |
| ▸ | EGFR | P00533 | 3/20 | 0.43 |
| ▸ | IDH1 | O75874 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4735694 | 0.85 | ABL1 (0.71) | ABL1BCRLCKRETCCNB2 | |
| SCHEMBL3228877 | 0.83 | ALDH1A1 (0.49) | ABL1BCRLCKRETCCNB2 | |
| SCHEMBL14041906 | 0.80 | ABL1 (0.78) | ABL1BCRLCKPRKCACAMKK2 | |
| SCHEMBL7601457 | 0.80 | ABL1 (0.78) | ABL1BCRLCKRETPRKCA | |
| SCHEMBL24885526 | 0.79 | ABL1 (0.66) | ABL1BCRLCKRETCCNB2 | |
| SCHEMBL30078200 | 0.79 | ABL1 (0.66) | ABL1BCRLCKRETCCNB2 | |
| SCHEMBL14041543 | 0.79 | ABL1 (0.69) | ABL1BCRLCKRETPRKCA | |
| SCHEMBL14041918 | 0.79 | ABL1 (0.63) | ABL1BCRLCKRETCDK1 | |
| Hydrochloric Acid SCHEMBL5205211 | 0.79 | ABL1 (0.76) | ABL1BCRLCKRETPRKCA | |
| SCHEMBL4893292 | 0.79 | ABL1 (0.65) | ABL1BCRLCKRETCCNB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8338417-B2 | Compounds and compositions as c-kit and PDGFR kinase inhibitors | IRM LLC (BM) | 2012-12-25 | — | — | US | disclosed |
| US-8338417-B2 | Compounds and compositions as c-kit and PDGFR kinase inhibitors | IRM LLC (BM) | 2012-12-25 | — | — | US | disclosed |
| US-20100234406-A1 | COMPOUNDS AND COMPOSITIONS AS C-KIT AND PDGFR KINASE INHIBITORS | IRM LLC (BM) | 2010-09-16 | — | — | US | disclosed |
| US-20100234406-A1 | COMPOUNDS AND COMPOSITIONS AS C-KIT AND PDGFR KINASE INHIBITORS | IRM LLC (BM) | 2010-09-16 | — | — | US | disclosed |
| US-20100048539-A1 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2010-02-25 | — | — | US | disclosed |
| US-20100048539-A1 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2010-02-25 | — | — | US | disclosed |
| US-20100048539-A1 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2010-02-25 | — | — | US | disclosed |
| WO-2008137794-A1 | COMPOUNDS AND COMPOSITIONS AS C-KIT AND PDGFR KINASE INHIBITORS | IRM LLC (BM) | 2008-11-13 | — | — | WO | disclosed |
| WO-2008058037-A1 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2008-05-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100048539-A1 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | PDGFRB, PDGFRA, KIT | ABL1 9/4885BCR 65/4885LCK 352/4885 |
| US-20100234406-A1 | COMPOUNDS AND COMPOSITIONS AS C-KIT AND PDGFR KINASE INHIBITORS | KIT, PDGFRA, PDGFRB | ABL1 10/4885BCR 95/4885LCK 406/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.