Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 7/20 | 0.78 |
| ▸ | BCR | P11274 | 6/20 | 0.78 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.65 |
| ▸ | LCK | P06239 | 1/20 | 0.64 |
| ▸ | PRKCA | P17252 | 3/20 | 0.56 |
| ▸ | EGFR | P00533 | 5/20 | 0.53 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.53 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.53 |
| ▸ | SRC | P12931 | 3/20 | 0.51 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.49 |
| ▸ | RET | P07949 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.49 |
| ▸ | PLK1 | P53350 | 1/20 | 0.49 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.49 |
| ▸ | PRKACA | P17612 | 1/20 | 0.49 |
| ▸ | PRKACG | P22612 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5205211 | 0.99 | ABL1 (0.76) | ABL1BCRCAMKK2LCKPRKCA | |
| SCHEMBL14041906 | 0.90 | ABL1 (0.78) | ABL1BCRCAMKK2LCKPRKCA | |
| SCHEMBL2580846 | 0.90 | ABL1 (0.74) | ABL1BCRCAMKK2LCKPRKCA | |
| SCHEMBL29366999 | 0.88 | ABL1 (1.00) | ABL1BCRPRKCAEGFRPDGFRB | |
| SCHEMBL2392 | 0.88 | ABL1 (1.00) | ABL1BCRPRKCAEGFRPDGFRB | |
| SCHEMBL29555505 | 0.88 | ABL1 (1.00) | ABL1BCRPRKCAEGFRPDGFRB | |
| Hydrochloric Acid SCHEMBL2419016 | 0.87 | ABL1 (0.98) | ABL1BCRPRKCAEGFRPDGFRB | |
| Ammonia Solution, Strong SCHEMBL4749564 | 0.87 | ABL1 (0.98) | ABL1BCRPRKCAEGFRPDGFRB | |
| SCHEMBL4893292 | 0.86 | ABL1 (0.65) | ABL1BCRCAMKK2LCKPRKCA | |
| SCHEMBL2575958 | 0.85 | ABL1 (0.78) | ABL1BCRCAMKK2LCKPRKCA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8183253-B2 | Condensing (3-trifluoromethylsulfonyl) benzoyl chloride and 4-methyl-2-nitro-aniline; reducing nitro group with stannous chloride; condensing amino group with cyanamide; cyclocondensing guanidine group with 3-dimethylamino-1-pyridin-3-yl-propenone; antiproliferative agents; chronic myeloid leukemia | NATCO PHARMA LIMITED (IN) | 2012-05-22 | — | — | US | disclosed |
| EP-1833815-B1 | A PROCESS FOR PREPARATION OF IMATINIB BASE | INST FARMACEUTYCZNY (PL) | 2010-09-15 | — | — | EP | disclosed |
| US-20080306100-A1 | PHENYLAMINOPYRIMIDINE DERIVATIVES AS INHIBITORS OF BCR-ABL KINASE | NATCO PHARMA LIMITED (IN) | 2008-12-11 | — | — | US | disclosed |
| US-7279576-B2 | Anti-cancer medicaments | DECIPHERA PHARMACEUTICALS, LLC (US) | 2007-10-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080306100-A1 | PHENYLAMINOPYRIMIDINE DERIVATIVES AS INHIBITORS OF BCR-ABL KINASE | ABL1, ABL2, BCR | ABL1 1/4885BCR 3/4885CAMKK2 612/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.