⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4398455 | 0.74 | — | — | |
| SCHEMBL11865606 | 0.70 | LMNA (0.43) | — | |
| SCHEMBL11555740 | 0.70 | LMNA (0.43) | — | |
| SCHEMBL13186521 | 0.70 | — | — | |
| SCHEMBL3126255 | 0.70 | — | — | |
| SCHEMBL1805763 | 0.70 | — | — | |
| SCHEMBL11583128 | 0.70 | LMNA (0.43) | — | |
| SCHEMBL7916442 | 0.70 | — | — | |
| SCHEMBL22479793 | 0.70 | — | — | |
| SCHEMBL11557297 | 0.70 | LMNA (0.43) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 37 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2142516-B1 | PYRIMIDINE HYDRAZIDE COMPOUNDS AS PGDS INHIBITORS | SANOFI SA (FR) | 2012-12-26 | — | — | EP | claimed |
| US-8258130-B2 | Pyrimidine hydrazide compounds as PGDS inhibitors | SANOFI (FR) | 2012-09-04 | — | — | US | claimed |
| US-20100048568-A1 | PYRIMIDINE HYDRAZIDE COMPOUNDS AS PGDS INHIBITORS | SANOFI-AVENTIS (FR) | 2010-02-25 | — | — | US | claimed |
| EP-2142516-A1 | PYRIMIDINE HYDRAZIDE COMPOUNDS AS PGDS INHIBITORS | Sanofi-Aventis (FR) | 2010-01-13 | — | — | EP | claimed |
| WO-2008121670-A1 | PYRIMIDINE HYDRAZIDE COMPOUNDS AS PGDS INHIBITORS | SANOFI-AVENTIS (FR) | 2008-10-09 | — | — | WO | claimed |
| EP-4638436-A1 | PRMT5 INHIBITORS AND USES THEREOF | GILEAD SCIENCES, INC. (US) | 2025-10-29 | — | — | EP | disclosed |
| US-20240254118-A1 | PRMT5 INHIBITORS AND USES THEREOF | GILEAD SCIENCES, INC. | 2024-08-01 | — | — | US | disclosed |
| WO-2024137852-A1 | PRMT5 INHIBITORS AND USES THEREOF | GILEAD SCIENCES, INC. (US) | 2024-06-27 | — | — | WO | disclosed |
| EP-3511327-B1 | TYROSINE KINASE INHIBITOR AND APPLICATION THEREOF | LANOVA MEDICINES LTD (CN) | 2021-10-27 | — | — | EP | disclosed |
| CN-112368285-A | Pyrrolotriazine compounds and methods of inhibiting TAM kinase | 希洛斯医药品股份有限公司 | 2021-02-12 | — | — | CN | disclosed |
| US-10882853-B2 | Tyrosine kinase inhibitor and application thereof | LaNova Medicines Limited (CN) | 2021-01-05 | — | — | US | disclosed |
| US-20190248772-A1 | TYROSINE KINASE INHIBITOR AND APPLICATION THEREOF | SHANGHAI XIANGJIN BIOTECHNOLOGY CO., LTD. (CN) | 2019-08-15 | — | — | US | disclosed |
| CN-1894214-A | New 5,6-dihydropyrin-2-one compounds useful as inhibitors of thrombin | ASTRAZENECA AB (SE) | 2007-01-10 | — | — | CN | disclosed |
| WO-2006135312-A1 | TROMBIN INHIBITING 2,4-DIOXO-3,4-DIHYDROPYRIMIDINE DERIVATIVES | ASTRAZENECA AB (SE) | 2006-12-21 | — | — | WO | disclosed |
| WO-2006135323-A1 | THROMBIN INHIBITING 2-OXO-1, 2, 5, 6-TETRAHYDROPYRIDINE DERIVATIVES | ASTRAZENECA AB (SE) | 2006-12-21 | — | — | WO | disclosed |
| EP-1713774-A1 | NEW PYRIDIN-2-ONE COMPOUNDS USEFUL AS INHIBITORS OF THROMBIN | AstraZeneca AB (SE) | 2006-10-25 | — | — | EP | disclosed |
| EP-1697323-A1 | NEW 5,6-DIHYDROPYRIN-2-ONE COMPOUNDS USEFUL AS INHIBITORS OF THROMBIN | AstraZeneca AB (SE) | 2006-09-06 | — | — | EP | disclosed |
| WO-2006061116-A1 | PYRAZINE DICARBOXAMIDES AND THE USE THEREOF | BAYER HEALTHCARE AG (DE) | 2006-06-15 | — | — | WO | disclosed |
| WO-2005075424-A1 | NEW PYRIDIN-2-ONE COMPOUNDS USEFUL AS INHIBITORS OF THROMBIN | ASTRAZENECA AB (SE) | 2005-08-18 | — | — | WO | disclosed |
| WO-2005058826-A1 | NEW 5,6-DIHYDROPYRIN-2-ONE COMPOUNDS USEFUL AS INHIBITORS OF THROMBIN | ASTRAZENECA AB (SE) | 2005-06-30 | — | — | WO | disclosed |