Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 5/20 | 0.47 |
| ▸ | MAOB | P27338 | 4/20 | 0.47 |
| ▸ | PRKCI | P41743 | 1/20 | 0.47 |
| ▸ | HSD17B1 | P14061 | 2/20 | 0.42 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 2/20 | 0.36 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | BCL2 | P10415 | 1/20 | 0.35 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | ELANE | P08246 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30067640 | 0.82 | MAOA (0.46) | MAOAMAOBPRKCIHSD17B1PBRM1 | |
| SCHEMBL7387407 | 0.81 | MAOA (0.44) | MAOAMAOBPRKCIHSD17B1BRD4 | |
| SCHEMBL3205385 | 0.81 | MAOA (0.44) | MAOAMAOBPRKCIHSD17B1PBRM1 | |
| SCHEMBL3218869 | 0.81 | MAOA (0.44) | MAOAMAOBPRKCIHSD17B1PBRM1 | |
| SCHEMBL30067281 | 0.81 | MAOA (0.44) | MAOAMAOBPRKCIHSD17B1PBRM1 | |
| SCHEMBL30067706 | 0.81 | MAOA (0.49) | MAOAMAOBPRKCIHSD17B1PBRM1 | |
| SCHEMBL30067499 | 0.78 | MAOA (0.42) | MAOAMAOBPRKCIHSD17B1PBRM1 | |
| SCHEMBL1838387 | 0.73 | MAOA (0.36) | MAOAMAOBPRKCIHSD17B1BRD4 | |
| SCHEMBL30067255 | 0.72 | PBRM1 (0.46) | MAOAMAOBPRKCIHSD17B1PBRM1 | |
| SCHEMBL388480 | 0.72 | PARP1 (0.53) | MAOAMAOBPRKCIBRD4CYP2A6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8263656-B2 | Substituted aminotetralines | HOFFMANN-LA ROCHE INC. (US) | 2012-09-11 | — | — | US | disclosed |
| US-8263656-B2 | Substituted aminotetralines | HOFFMANN-LA ROCHE INC. (US) | 2012-09-11 | — | — | US | disclosed |
| US-8263656-B2 | Substituted aminotetralines | HOFFMANN-LA ROCHE INC. (US) | 2012-09-11 | — | — | US | disclosed |
| WO-2010018109-A2 | SUBSTITUTED AMINOTETRALINES | F. HOFFMANN-LA ROCHE AG (CH) | 2010-02-18 | — | — | WO | disclosed |
| US-20100041713-A1 | SUBSTITUTED AMINOTETRALINES | FIROOZNIA FARIBORZ | 2010-02-18 | — | — | US | disclosed |
| US-20100041713-A1 | SUBSTITUTED AMINOTETRALINES | FIROOZNIA FARIBORZ | 2010-02-18 | — | — | US | disclosed |
| US-20100041713-A1 | SUBSTITUTED AMINOTETRALINES | FIROOZNIA FARIBORZ | 2010-02-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100041713-A1 | SUBSTITUTED AMINOTETRALINES | HRH4, HRH1, HRH2 | MAOA 2001/4885MAOB 1561/4885PRKCI 3692/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.