Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.53 |
| ▸ | BRD4 | O60885 | 2/20 | 0.49 |
| ▸ | MAOB | P27338 | 4/20 | 0.48 |
| ▸ | MAOA | P21397 | 4/20 | 0.48 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.48 |
| ▸ | BAD | Q92934 | 1/20 | 0.48 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.48 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.43 |
| ▸ | PRKCI | P41743 | 1/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 3/20 | 0.41 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.41 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21772776 | 0.98 | PARP1 (0.51) | PARP1BRD4MAOBMAOABCL2L1 | |
| SCHEMBL14120724 | 0.96 | BCL2L1 (0.53) | PARP1BRD4MAOBMAOABCL2L1 | |
| SCHEMBL29392687 | 0.88 | PARP1 (0.56) | PARP1MAOBMAOABCL2L1BAD | |
| SCHEMBL389461 | 0.88 | PARP1 (0.56) | PARP1MAOBMAOABCL2L1BAD | |
| SCHEMBL1151194 | 0.78 | PARP1 (0.55) | PARP1BRD4MAOBMAOACYP2A6 | |
| SCHEMBL29501042 | 0.78 | PARP1 (0.55) | PARP1BRD4MAOBMAOACYP2A6 | |
| SCHEMBL5540741 | 0.78 | MAOA (0.50) | BRD4MAOBMAOACYP2A6MRGPRX4 | |
| SCHEMBL1759573 | 0.77 | MRGPRX4 (0.51) | BRD4MAOBMAOACYP2A6MRGPRX4 | |
| SCHEMBL9521410 | 0.76 | ACHE (0.53) | BRD4MAOBMAOACYP2A6PRKCI | |
| SCHEMBL14431629 | 0.76 | BCL2L1 (0.48) | PARP1BRD4MAOBMAOABCL2L1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 548 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115364144-A | Yuqing lobular Kuding tea extract and preparation method and application thereof | 贵州省中国科学院天然产物化学重点实验室(贵州医科大学天然产物化学重点实验室) | 2022-11-22 | — | — | CN | claimed |
| US-20220340539-A1 | COMPOUND AND PREPARATION METHOD THEREFOR AND USE THEREOF | GENEORA PHARMA (SHIJIAZHUANG) CO., LTD. (CN) | 2022-10-27 | — | — | US | claimed |
| EP-4039678-A1 | COMPOUND AND PREPARATION METHOD THEREFOR AND USE THEREOF | Shandong Luye Pharmaceutical Co., Ltd. (CN) | 2022-08-10 | — | — | EP | claimed |
| CN-114423746-A | Compound and preparation method and application thereof | 山东绿叶制药有限公司 | 2022-04-29 | — | — | CN | claimed |
| CN-109160882-B | Preparation method of levobunolol hydrochloride | 杭州师范大学 | 2021-07-09 | — | — | CN | claimed |
| WO-2021063347-A1 | COMPOUND AND PREPARATION METHOD THEREFOR AND USE THEREOF | 山东绿叶制药有限公司 | 2021-04-08 | — | — | WO | claimed |
| US-10611721-B2 | Method for preparing levobunolol hydrochloride | HANGZHOU NORMAL UNIVERSITY (CN) | 2020-04-07 | — | — | US | claimed |
| US-20200071259-A1 | Method for Preparing Levobunolol Hydrochloride | HANGZHOU NORMAL UNIVERSITY (CN) | 2020-03-05 | — | — | US | claimed |
| CN-108722396-B | A kind of preparation method of 5- hydroxyl -1-tetralone | 杭州卢普生物科技有限公司 | 2019-08-06 | — | — | CN | claimed |
| CN-109160882-A | A kind of preparation method of Levobunolol Hydrochorid | 杭州师范大学 | 2019-01-08 | — | — | CN | claimed |
| US-10092786-B2 | Fire extinguishing composition comprising aldoketones compound | XI'AN WESTPEACE FIRE TECHNOLOGY CO., LTD. (CN) | 2018-10-09 | — | — | US | claimed |
| US-20160332016-A1 | Fire Extinguishing Composition Comprising Aldoketones Compound | NANO FIRE, LLC | 2016-11-17 | — | — | US | claimed |
| EP-2194035-B1 | Hydroxytetralones | SALTIGO GMBH (DE) | 2011-11-02 | — | — | EP | claimed |
| CN-101140278-A | Animals urine checking method, detecting and preparation method | SHIAN LIU (CN) | 2008-03-12 | — | — | CN | claimed |
| CN-1676513-A | Novel anti-hypertension chemical entity (TMEP) | TIAN SHIXIONG (CN) | 2005-10-05 | — | — | CN | claimed |
| US-5618982-A | SIMPLE INDUSTRIAL PROCESS OF CATALYZING IN PRESENCE OF METALLIC PHOSPHATES | RHONE-POULENC CHIMIE (FR) | 1997-04-08 | — | — | US | claimed |
| US-5426227-A | Enantioselective process for the preparation of leveobunolol | MEDICHAM, S.A. (ES) | 1995-06-20 | — | — | US | claimed |
| JP-5194459-A | — | — | None | — | — | JP | disclosed |
| US-4018824-A | ANTIULCER AND ADRENERGIC BLOCKING AGENTS | TEIKOKU HORMONE MFG. CO., LTD. (JA) | 1977-04-19 | — | — | US | disclosed |
| US-3932411-A | HYPOTENSIVE, TRANQUILIZERS, SEDATIVES, ANTIEDEMIC | BOEHRINGER MANNHEIM G.M.B.H. (DT) | 1976-01-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10611721-B2 | Method for preparing levobunolol hydrochloride | SQLE, TET1, CYP7A1 | PARP1 2655/4885BRD4 1104/4885MAOB 141/4885 |
| US-20200071259-A1 | Method for Preparing Levobunolol Hydrochloride | SQLE, TET1, CYP7A1 | PARP1 2655/4885BRD4 1104/4885MAOB 141/4885 |
| US-20220340539-A1 | COMPOUND AND PREPARATION METHOD THEREFOR AND USE THEREOF | FURIN, VIP, SORD | PARP1 4014/4885BRD4 3516/4885MAOB 340/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.