SCHEMBL3214890

SCHEMBL3214890

CSC(Oc1cc2cc(I)cnc2cc1F)C(=O)NC(C)(C)C

nearest known ligand 0.33

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
HPGDS O60760 1/20 0.33
SCN9A Q15858 1/20 0.32
PDGFRB P09619 1/20 0.31
PDGFRA P16234 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3214779 0.87 AAK1 (0.33) HPGDSSCN9APDGFRBPDGFRA
SCHEMBL3206673 0.87 PDGFRB (0.34) PDGFRBPDGFRA
SCHEMBL3729101 0.85 PDGFRB (0.32) HPGDSSCN9APDGFRBPDGFRA
SCHEMBL1926439 0.83 HPGDS (0.38) HPGDSSCN9APDGFRBPDGFRA
SCHEMBL3724305 0.82 PDGFRB (0.34) HPGDSPDGFRBPDGFRA
SCHEMBL3224139 0.82 PDGFRB (0.36) PDGFRBPDGFRA
SCHEMBL3219234 0.81 PDGFRB (0.51) PDGFRBPDGFRA
SCHEMBL3739222 0.77 MEN1 (0.33) PDGFRBPDGFRA
SCHEMBL3740907 0.75 MAPK14 (0.30)
SCHEMBL3730447 0.75 PDGFRB (0.32) PDGFRBPDGFRA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20100056570-A1 FUNGICIDES SYNGENTA CROP PROTECTION, INC. (US) 2010-03-04 US disclosed
EP-2068632-A1 FUNGICIDES Syngeta Participations AG (CH) 2009-06-17 EP disclosed
WO-2008028624-A1 FUNGICIDES SYNGENTA PARTICIPATIONS AG (CH) 2008-03-13 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100056570-A1 FUNGICIDES CYP21A2, CYP51A1, CYP4X1 HPGDS 4806/4885SCN9A 1443/4885PDGFRB 4516/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.