Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.38 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.38 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | NAMPT | P43490 | 1/20 | 0.36 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.35 |
| ▸ | IMPDH1 | P20839 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | SREBF1 | P36956 | 1/20 | 0.35 |
| ▸ | GRM7 | Q14831 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3201229 | 0.96 | TP53 (0.38) | TSHRMAPK1L3MBTL1HPGDGPR119 | |
| SCHEMBL3192199 | 0.95 | HRH4 (0.39) | MAPK1L3MBTL1HPGDGPR119HRH4 | |
| SCHEMBL3129701 | 0.92 | SREBF1 (0.40) | TSHRMAPK1L3MBTL1HPGDGPR119 | |
| SCHEMBL3214119 | 0.90 | GPR119 (0.40) | GPR119AAK1IMPDH2MCHR1 | |
| SCHEMBL3202834 | 0.90 | RXRA (0.40) | MAPK1GPR119HRH4AAK1ALDH1A1 | |
| SCHEMBL3123133 | 0.89 | SREBF1 (0.37) | TSHRMAPK1L3MBTL1HPGDGPR119 | |
| SCHEMBL3249961 | 0.88 | GPR119 (0.39) | GPR119AAK1NAMPTIMPDH2IMPDH1 | |
| SCHEMBL3126123 | 0.88 | HRH4 (0.38) | MAPK1GPR119HRH4AAK1NAMPT | |
| SCHEMBL3200044 | 0.88 | TSHR (0.52) | TSHRMAPK1L3MBTL1HPGDHRH4 | |
| SCHEMBL3193658 | 0.88 | POLB (0.40) | TSHRMAPK1L3MBTL1GPR119AAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100029689-A1 | PHOSPHODIESTERASE 4 INHIBITORS | MEMORY PHARMACEUTICALS CORPORATION (US) | 2010-02-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100029689-A1 | PHOSPHODIESTERASE 4 INHIBITORS | PDE4A, PDE4B, PDE3B | TSHR 1908/4885MAPK1 1371/4885L3MBTL1 3388/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.