Sugi Predict

Sugi Predict / Compounds / SCHEMBL3216038

SCHEMBL3216038

SCHEMBL3216038

CCOc1cc(N(Cc2cnco2)c2cccc(CC(=O)O)c2)ccc1OC(F)F

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ CYP4F2 P78329 1/20 0.39
▸ CYP4A11 Q02928 1/20 0.39
▸ HRH4 Q9H3N8 1/20 0.38
▸ AAK1 Q2M2I8 2/20 0.34
▸ CIT O14578 1/20 0.34
▸ GAK O14976 1/20 0.34
▸ PRKX P51817 1/20 0.34
▸ PRKCQ Q04759 1/20 0.34
▸ HASPIN Q8TF76 1/20 0.34
▸ MKNK1 Q9BUB5 1/20 0.34
▸ CLK4 Q9HAZ1 1/20 0.34
▸ MKNK2 Q9HBH9 1/20 0.34
▸ BMP2K Q9NSY1 1/20 0.34
▸ PPARG P37231 1/20 0.34
▸ NR1H2 P55055 1/20 0.34
▸ PPARD Q03181 1/20 0.34
▸ PPARA Q07869 1/20 0.34
▸ NR1H3 Q13133 1/20 0.34
▸ PDE4B Q07343 3/20 0.34
▸ PDE4A P27815 2/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3131933 0.92 HRH4 (0.41) CYP4F2CYP4A11HRH4AAK1CIT
SCHEMBL3203958 0.92 HRH4 (0.37) HRH4AAK1CITGAKPRKX
SCHEMBL3117544 0.88 HRH4 (0.39) HRH4AAK1CITGAKPRKX
SCHEMBL3123335 0.85 RXRA (0.42) HRH4AAK1CITGAKPRKX
SCHEMBL3205713 0.85 HRH4 (0.38) HRH4PPARGNR1H2PPARDPPARA
SCHEMBL3203252 0.84 HRH4 (0.40) HRH4AAK1CITGAKPRKX
SCHEMBL3130978 0.83 HRH4 (0.36) HRH4AAK1CITGAKPRKX
SCHEMBL3127864 0.81 HRH4 (0.41) HRH4AAK1CITGAKPRKX
SCHEMBL3129226 0.80 PDE4B (0.42) PPARGNR1H2PPARDPPARANR1H3
SCHEMBL3214199 0.80 HRH4 (0.40) HRH4AAK1CITGAKPRKX

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20100029689-A1 PHOSPHODIESTERASE 4 INHIBITORS MEMORY PHARMACEUTICALS CORPORATION (US) 2010-02-04 — — US claimed
WO-2010003084-A2 PHOSPHODIESTERASE 4 INHIBITORS MEMORY PHARMACEUTICALS CORPORATION (US) 2010-01-07 — — WO claimed
US-20100029689-A1 PHOSPHODIESTERASE 4 INHIBITORS MEMORY PHARMACEUTICALS CORPORATION (US) 2010-02-04 — — US disclosed
US-20100029689-A1 PHOSPHODIESTERASE 4 INHIBITORS MEMORY PHARMACEUTICALS CORPORATION (US) 2010-02-04 — — US disclosed
US-20100029689-A1 PHOSPHODIESTERASE 4 INHIBITORS MEMORY PHARMACEUTICALS CORPORATION (US) 2010-02-04 — — US disclosed
WO-2010003084-A2 PHOSPHODIESTERASE 4 INHIBITORS MEMORY PHARMACEUTICALS CORPORATION (US) 2010-01-07 — — WO disclosed
WO-2010003084-A2 PHOSPHODIESTERASE 4 INHIBITORS MEMORY PHARMACEUTICALS CORPORATION (US) 2010-01-07 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100029689-A1 PHOSPHODIESTERASE 4 INHIBITORS PDE4A, PDE4B, PDE3B CYP4F2 366/4885CYP4A11 54/4885HRH4 442/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.