Sugi Predict

Sugi Predict / Compounds / SCHEMBL3205713

SCHEMBL3205713

SCHEMBL3205713

CCOc1cc(N(Cc2cncs2)c2cccc(CC(=O)O)c2)ccc1OC(F)F

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ HRH4 Q9H3N8 1/20 0.38
▸ RAB9A P51151 1/20 0.35
▸ RORC P51449 1/20 0.35
▸ TRPM8 Q7Z2W7 1/20 0.35
▸ CYP3A4 P08684 5/20 0.34
▸ PPARG P37231 1/20 0.34
▸ NR1H2 P55055 1/20 0.34
▸ PPARD Q03181 1/20 0.34
▸ PPARA Q07869 1/20 0.34
▸ NR1H3 Q13133 1/20 0.34
▸ PDE4B Q07343 2/20 0.34
▸ PDE4A P27815 1/20 0.34
▸ PDE4C Q08493 1/20 0.34
▸ PDE4D Q08499 1/20 0.34
▸ MEN1 O00255 2/20 0.33
▸ KMT2A Q03164 2/20 0.33
▸ LMNA P02545 1/20 0.33
▸ MAPT P10636 1/20 0.33
▸ MAPK1 P28482 1/20 0.33
▸ RXRA P19793 2/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3200782 0.93 PDE4A (0.39) RORCCYP3A4PDE4BPDE4APDE4C
SCHEMBL3218633 0.92 HRH4 (0.37) HRH4RAB9ATRPM8CYP3A4PDE4B
SCHEMBL3128993 0.88 HRH4 (0.39) HRH4RAB9ATRPM8PPARGPPARA
SCHEMBL3207786 0.87 TRPM8 (0.35) HRH4RAB9ATRPM8CYP3A4PDE4B
SCHEMBL3125660 0.85 RXRA (0.42) HRH4RAB9ATRPM8PPARGMEN1
SCHEMBL3216038 0.85 CYP4F2 (0.39) HRH4RAB9ARORCPPARGNR1H2
SCHEMBL3215275 0.85 PDE4A (0.42) HRH4RORCTRPM8CYP3A4PDE4B
SCHEMBL3201201 0.83 HRH4 (0.36) HRH4RAB9ATRPM8NR1H2NR1H3
SCHEMBL3129667 0.81 HRH4 (0.41) HRH4RAB9ATRPM8PDE4BMEN1
SCHEMBL3129699 0.81 RXRA (0.42) PDE4BPDE4DLMNARXRAPTPN11

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20100029689-A1 PHOSPHODIESTERASE 4 INHIBITORS MEMORY PHARMACEUTICALS CORPORATION (US) 2010-02-04 — — US claimed
WO-2010003084-A2 PHOSPHODIESTERASE 4 INHIBITORS MEMORY PHARMACEUTICALS CORPORATION (US) 2010-01-07 — — WO claimed
US-20100029689-A1 PHOSPHODIESTERASE 4 INHIBITORS MEMORY PHARMACEUTICALS CORPORATION (US) 2010-02-04 — — US disclosed
US-20100029689-A1 PHOSPHODIESTERASE 4 INHIBITORS MEMORY PHARMACEUTICALS CORPORATION (US) 2010-02-04 — — US disclosed
US-20100029689-A1 PHOSPHODIESTERASE 4 INHIBITORS MEMORY PHARMACEUTICALS CORPORATION (US) 2010-02-04 — — US disclosed
WO-2010003084-A2 PHOSPHODIESTERASE 4 INHIBITORS MEMORY PHARMACEUTICALS CORPORATION (US) 2010-01-07 — — WO disclosed
WO-2010003084-A2 PHOSPHODIESTERASE 4 INHIBITORS MEMORY PHARMACEUTICALS CORPORATION (US) 2010-01-07 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100029689-A1 PHOSPHODIESTERASE 4 INHIBITORS PDE4A, PDE4B, PDE3B HRH4 442/4885RAB9A 2160/4885RORC 3048/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.