Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FDPS | P14324 | 3/20 | 0.35 |
| ▸ | DNM1 | Q05193 | 8/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL5087902 | 0.92 | FDPS (0.35) | FDPSDNM1ALDH1A1TDP1 | |
| Bromide SCHEMBL3229156 | 0.90 | DNM1 (0.43) | FDPSDNM1ALDH1A1TDP1MEN1 | |
| SCHEMBL302193 | 0.89 | FDPS (0.37) | FDPSDNM1ALDH1A1TDP1TSHR | |
| Bromide SCHEMBL3219480 | 0.89 | DNM1 (0.46) | FDPSDNM1ALDH1A1TDP1MEN1 | |
| Bromide SCHEMBL3126204 | 0.88 | FDPS (0.33) | FDPSDNM1ALDH1A1TDP1 | |
| Bromide SCHEMBL3916851 | 0.88 | FDPS (0.41) | FDPSDNM1ALDH1A1TDP1CYP3A4 | |
| Fluoride SCHEMBL8161717 | 0.87 | FDPS (0.35) | FDPSDNM1ALDH1A1TDP1 | |
| Iodide SCHEMBL5091363 | 0.87 | FDPS (0.35) | FDPSDNM1ALDH1A1TDP1 | |
| Hydrochloric Acid SCHEMBL5088126 | 0.87 | FDPS (0.35) | FDPSDNM1ALDH1A1TDP1 | |
| Water SCHEMBL28462530 | 0.87 | FDPS (0.35) | FDPSDNM1ALDH1A1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7834134-B2 | Polyarylethers, blends and methods for making | GENERAL ELECTRIC COMPANY (US) | 2010-11-16 | — | — | US | disclosed |
| US-20100041837-A1 | POLYARYLETHERS, BLENDS AND METHODS FOR MAKING | GENERAL ELECTRIC COMPANY | 2010-02-18 | — | — | US | disclosed |
| US-20100041838-A1 | POLYARYLETHERS, BLENDS AND METHODS FOR MAKING | BL TECHNOLOGIES, INC. | 2010-02-18 | — | — | US | disclosed |
| EP-0141692-B1 | BIS-QUATERNARY SALTS AS PHASE TRANSFER CATALYSTS FOR AROMATIC ETHER IMIDE PREPARATION | GENERAL ELECTRIC COMPANY (US) | 1989-10-25 | — | — | EP | disclosed |
| US-4554357-A | NUCLEOPHILIC DISPLACEMENT | GENERAL ELECTRIC COMPANY (US) | 1985-11-19 | — | — | US | disclosed |