Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 1/20 | 1.00 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.53 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.53 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.53 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.53 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.53 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.50 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL873067 | 0.89 | CHRNA7 (0.79) | CHRNA7CHRM2CHRM4CHRM5CHRM1 | |
| Hydrochloric Acid SCHEMBL8686664 | 0.87 | CHRNA7 (0.77) | CHRNA7CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL8777870 | 0.84 | CHRNA7 (0.72) | CHRNA7CHRM2CHRM4CHRM5CHRM1 | |
| Hydrochloric Acid SCHEMBL8688078 | 0.83 | CHRNA7 (0.70) | CHRNA7CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL11300641 | 0.80 | CHRNA7 (0.67) | CHRNA7CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL9431069 | 0.80 | CHRNA7 (0.67) | CHRNA7CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL6628801 | 0.80 | CHRNA7 (0.66) | CHRNA7CHRNB4CHRNA3LMNA | |
| SCHEMBL23763949 | 0.78 | CHRNA7 (0.64) | CHRNA7CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL9677934 | 0.78 | CHRNA7 (0.64) | CHRNA7CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL4689211 | 0.78 | CHRNA7 (0.64) | CHRNA7CHRM2CHRM4CHRM5CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130261114-A1 | COMPOUNDS USEFUL AS INHIBITORS OF CHOLINE KINASE | VERTEX PHARMACEUTICALS INCORPORATED | 2013-10-03 | — | — | US | disclosed |
| US-20100056565-A1 | Heterocyclic Derivatives as M3 Muscarinic Receptors | ARGENTA DISCOVERY LIMITED (GB) | 2010-03-04 | — | — | US | disclosed |
| EP-2121688-A1 | HETEROCYCLIC DERIVATIVES AS M3 MUSCARINIC RECEPTORS | Argenta Discovery Ltd (GB) | 2009-11-25 | — | — | EP | disclosed |
| WO-2008099186-A1 | HETEROCYCLIC DERIVATIVES AS M3 MUSCARINIC RECEPTORS | ARGENTA DISCOVERY LIMITED (GB) | 2008-08-21 | — | — | WO | disclosed |
| US-4292190-A | ANTIFREEZES FOR COOLING SYSTEMS OF INTERNAL COMBUSTION ENGINES | BASF WYANDOTTE CORPORATION (US) | 1981-09-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130261114-A1 | COMPOUNDS USEFUL AS INHIBITORS OF CHOLINE KINASE | CHKA, CHKB, PHKG1 | CHRNA7 655/4885CHRM2 654/4885CHRM4 718/4885 |
| US-20100056565-A1 | Heterocyclic Derivatives as M3 Muscarinic Receptors | CHRM2, CHRM3, CHRM1 | CHRNA7 13/4885CHRM2 1/4885CHRM4 5/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.