Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 1/20 | 0.42 |
| ▸ | BACE1 | P56817 | 5/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | TLR2 | O60603 | 1/20 | 0.39 |
| ▸ | ERN1 | O75460 | 1/20 | 0.39 |
| ▸ | TLR1 | Q15399 | 1/20 | 0.39 |
| ▸ | TLR6 | Q9Y2C9 | 1/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.39 |
| ▸ | FYN | P06241 | 1/20 | 0.39 |
| ▸ | CSF1R | P07333 | 1/20 | 0.39 |
| ▸ | RET | P07949 | 1/20 | 0.39 |
| ▸ | IGF1R | P08069 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL34462800 | 0.94 | BACE1 (0.45) | PTPN1BACE1ALDH1A1SMN1; SMN2TLR2 | |
| SCHEMBL3205905 | 0.94 | BACE1 (0.45) | PTPN1BACE1ALDH1A1SMN1; SMN2TLR2 | |
| SCHEMBL12855017 | 0.88 | BACE1 (0.38) | PTPN1BACE1ALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL6683418 | 0.88 | ALDH1A1 (0.40) | PTPN1BACE1ALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL20279251 | 0.88 | ERN1 (0.42) | PTPN1BACE1ALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL10922927 | 0.88 | BACE1 (0.52) | PTPN1BACE1ALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL20541205 | 0.88 | ALDH1A1 (0.52) | PTPN1BACE1ALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL27252704 | 0.87 | MAPT (0.55) | SMN1; SMN2ERN1L3MBTL1TDP1GAA | |
| SCHEMBL29122166 | 0.87 | BACE1 (0.36) | PTPN1BACE1ALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL21828929 | 0.84 | CLCN2 (0.45) | PTPN1BACE1ALDH1A1HPGDHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 52 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250032471-A1 | Crystalline Polymorphs of the Free Base of 2-Hydroxy-6-((2-(1-isopropyl-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)benzaldehyde | GLOBAL BLOOD THERAPEUTICS INC (US) | 2025-01-30 | — | — | US | disclosed |
| EP-3102208-B2 | CRYSTALLINE POLYMORPH OF THE FREE BASE OF 2-HYDROXY-6-((2-(1-ISOPROPYL-1H-PYRAZOL-5-YL)PYRIDIN-3-YL)METHOXY)BENZALDEHYDE | GLOBAL BLOOD THERAPEUTICS INC (US) | 2024-07-17 | — | — | EP | disclosed |
| CN-115636742-B | Recrystallization method | 江西亚太科技发展有限公司 | 2024-04-09 | — | — | CN | disclosed |
| CN-115636742-A | Recrystallization method | 江西亚太科技发展有限公司 | 2023-01-24 | — | — | CN | disclosed |
| US-20220395492-A1 | CRYSTALLINE POLYMORPHS OF THE FREE BASE OF 2-HYDROXY-6-((2-(1-ISOPROPYL-1H-PYRAZOL-5-YL)PYRIDIN-3-YL)METHOXY)BENZALDEHYDE | GLOBAL BLOOD THERAPEUTICS, INC. | 2022-12-15 | — | — | US | disclosed |
| US-11452720-B2 | Crystalline polymorphs of the free base of 2-hydroxy-6-((2-(1-isopropyl-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)benzaldehyde | GLOBAL BLOOD THERAPEUTICS, INC. (US) | 2022-09-27 | — | — | US | disclosed |
| CN-114213390-A | Crystalline polymorph of a compound | 全球血液疗法股份有限公司 | 2022-03-22 | — | — | CN | disclosed |
| CN-114181194-A | Crystalline polymorph of a compound | 全球血液疗法股份有限公司 | 2022-03-15 | — | — | CN | disclosed |
| CN-114181195-A | Crystalline polymorph of a compound | 全球血液疗法股份有限公司 | 2022-03-15 | — | — | CN | disclosed |
| US-20210161876-A1 | CRYSTALLINE POLYMORPHS OF THE FREE BASE OF 2-HYDROXY-6-((2-(1-ISOPROPYL-1H-PYRAZOL-5-YL)PYRIDIN-3-YL)METHOXY)BENZALDEHYDE | GLOBAL BLOOD THERAPEUTICS, INC. | 2021-06-03 | — | — | US | disclosed |
| US-20150057251-A1 | COMPOUNDS AND USES THEREOF FOR THE MODULATION OF HEMOGLOBIN | GLOBAL BLOOD THERAPEUTICS, INC. | 2015-02-26 | — | — | US | disclosed |
| US-20150057251-A1 | COMPOUNDS AND USES THEREOF FOR THE MODULATION OF HEMOGLOBIN | GLOBAL BLOOD THERAPEUTICS, INC. | 2015-02-26 | — | — | US | disclosed |
| US-8962674-B2 | Curcumin derivative | TOKYO INSTITUTE OF TECHNOLOGY (JP) | 2015-02-24 | — | — | US | disclosed |
| WO-2014145040-A1 | SUBSTITUTED ALDEHYDE COMPOUNDS AND METHODS FOR THEIR USE IN INCREASING TISSUE OXYGENATION | GLOBAL BLOOD THERAPEUTICS, INC. (US) | 2014-09-18 | — | — | WO | disclosed |
| WO-2014145040-A1 | SUBSTITUTED ALDEHYDE COMPOUNDS AND METHODS FOR THEIR USE IN INCREASING TISSUE OXYGENATION | GLOBAL BLOOD THERAPEUTICS, INC. (US) | 2014-09-18 | — | — | WO | disclosed |
| US-20100048901-A1 | NOVEL CURCUMIN DERIVATIVE | TOKYO INSTITUTE OF TECHNOLOGY (JP) | 2010-02-25 | — | — | US | disclosed |
| EP-2123637-A1 | NOVEL CURCUMIN DERIVATIVE | Tokyo Institute of Technology (JP) | 2009-11-25 | — | — | EP | disclosed |
| EP-0210140-B1 | INHIBITORS OF BENZYLAMINOXIDASES, SELECTIVE WITH RESPECT TO OTHER AMINOXIDASES | CONSIGLIO NAZIONALE DELLE RICERCHE (IT) | 1990-06-13 | — | — | EP | disclosed |
| US-4888283-A | Selective inhibitors of benzylaminoxidases with respect to other aminoxidases | CONSIGLIO NAZIONALE DELLE RICERCHE (IT) | 1989-12-19 | — | — | US | disclosed |
| EP-0210140-A2 | Inhibitors of benzylaminoxidases, selective with respect to other aminoxidases | CONSIGLIO NAZIONALE DELLE RICERCHE (IT) | 1987-01-28 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100048901-A1 | NOVEL CURCUMIN DERIVATIVE | BACE1, APP, BACE2 | PTPN1 4355/4885BACE1 1/4885ALDH1A1 253/4885 |
| US-20250032471-A1 | Crystalline Polymorphs of the Free Base of 2-Hydroxy-6-((2-(1-isopropyl-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)benzaldehyde | H1-0, INF2, H1-2 | PTPN1 2565/4885BACE1 3422/4885ALDH1A1 139/4885 |
| US-20210161876-A1 | CRYSTALLINE POLYMORPHS OF THE FREE BASE OF 2-HYDROXY-6-((2-(1-ISOPROPYL-1H-PYRAZOL-5-YL)PYRIDIN-3-YL)METHOXY)BENZALDEHYDE | H1-0, INF2, H1-2 | PTPN1 2565/4885BACE1 3422/4885ALDH1A1 139/4885 |
| US-11452720-B2 | Crystalline polymorphs of the free base of 2-hydroxy-6-((2-(1-isopropyl-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)benzaldehyde | H1-0, INF2, H1-2 | PTPN1 2565/4885BACE1 3422/4885ALDH1A1 139/4885 |
| US-20150057251-A1 | COMPOUNDS AND USES THEREOF FOR THE MODULATION OF HEMOGLOBIN | HBG2, HBG1, HBB | PTPN1 2468/4885BACE1 4551/4885ALDH1A1 1089/4885 |
| US-20220395492-A1 | CRYSTALLINE POLYMORPHS OF THE FREE BASE OF 2-HYDROXY-6-((2-(1-ISOPROPYL-1H-PYRAZOL-5-YL)PYRIDIN-3-YL)METHOXY)BENZALDEHYDE | H1-0, INF2, H1-2 | PTPN1 2565/4885BACE1 3422/4885ALDH1A1 139/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.