SCHEMBL3219429

SCHEMBL3219429

COc1ccc(OCc2ccccc2)cc1CBr

nearest known ligand 0.70

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
MAOB P27338 4/20 0.55
L3MBTL1 Q9Y468 2/20 0.51
BCHE P06276 2/20 0.51
ALOX5 P09917 1/20 0.50
ALDH1A1 P00352 1/20 0.49
LMNA P02545 1/20 0.49
MAPT P10636 1/20 0.49
ALOX12 P18054 1/20 0.49
PDGFRB P09619 1/20 0.48
PDGFRA P16234 1/20 0.48
ABCB1 P08183 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28330023 0.89 ALOX5 (0.54) MAOBL3MBTL1ALOX5ALDH1A1LMNA
SCHEMBL30148504 0.85 MAOB (0.53) MAOBL3MBTL1BCHEALOX5ALDH1A1
SCHEMBL27635062 0.85 MAOB (0.55) MAOBL3MBTL1BCHEALOX5ALDH1A1
SCHEMBL7273091 0.85 MAOB (0.55) MAOBL3MBTL1BCHEALOX5ALDH1A1
SCHEMBL4028358 0.84 ABCB1 (0.47) MAOBALOX5ALDH1A1ABCB1
SCHEMBL30148511 0.83 MAOB (0.60) MAOBL3MBTL1ALOX5ALDH1A1LMNA
SCHEMBL8184228 0.83 MAOB (0.60) MAOBL3MBTL1ALOX5ALDH1A1LMNA
SCHEMBL6382816 0.82 ADRA1A (0.65) MAPT
SCHEMBL8762006 0.82 ALOX5 (0.58) MAOBL3MBTL1ALOX5LMNAMAPT
SCHEMBL6035496 0.81 MAOB (0.55) MAOBL3MBTL1BCHEALOX5ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 39 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20040234592-A1 Mixture containing thyroid hormone , ethanolamine and emulsifier KARO BIO AB (SE) 2004-11-25 US claimed
CN-1518469-A Dermatological preparations �����ɷ� 2004-08-04 CN claimed
EP-1404413-A2 DERMATOLOGICAL FORMULATIONS KARO BIO AB (SE) 2004-04-07 EP claimed
EP-1398024-A2 Uses for thyroid hormone compounds KARO BIO AB (SE) 2004-03-17 EP claimed
EP-0831769-B1 NOVEL USES FOR THYROID HORMONES OR THYROID HORMONE-LIKE COMPOUNDS KAROBIO AB (SE) 2003-10-15 EP claimed
EP-1328265-A2 NOVEL USES FOR THYROID HORMONES OR THYROID HORMONE-LIKE AGONIST COMPOUNDS FOR TREATING DERMIS CONDITIONS KARO BIO AB (SE) 2003-07-23 EP claimed
WO-2002089917-A2 DERMATOLOGICAL FORMULATIONS KARO BIO AB (SE) 2002-11-14 WO claimed
US-20020123521-A1 Treatment for dermal skin atrophy using thyroid hormone compounds or thyroid hormone-like compounds KOO, CATHERINE, DR 2002-09-05 US claimed
US-6380255-B1 TOPICALLY APPLYING TO SKIN THYROID HORMONE COMPOUND TOGETHER WITH A BASE FOR THERAPY OF SKIN ATROPHY KARO BIO AB (SE) 2002-04-30 US claimed
WO-2002005834-A2 NOVEL USES FOR THYROID HORMONES OR THYROID HORMONE-LIKE AGONIST COMPOUNDS FOR TREATING DERMIS CONDITIONS KARO BIO AB (SE) 2002-01-24 WO claimed
US-6221911-B1 REDUCING SUBCUTANEOUS FAT DEPOSITS IN A SUBJECT; IMPROVING THE SKIN CONDITION OF A SUBJECT KARO BIO AB (SE) 2001-04-24 US claimed
EP-0831769-A2 NOVEL USES FOR THYROID HORMONES OR THYROID HORMONE-LIKE COMPOUNDS KARO BIO AB (SE) 1998-04-01 EP claimed
WO-1996040048-A9 NOVEL USES FOR THYROID HORMONES OR THYROID HORMONE-LIKE COMPOUNDS 1997-03-27 WO claimed
WO-1996040048-A2 NOVEL USES FOR THYROID HORMONES OR THYROID HORMONE-LIKE COMPOUNDS KARO BIO AB (SE) 1996-12-19 WO claimed
US-20100047332-A1 Treatments for burns using thyroid hormone compound in a human KOO, CATHERINE, DR 2010-02-25 US disclosed
CN-101291640-A Thyroxine compounds for the treatment of burns and fat deposits in humans THOMAS LAVIN (US) 2008-10-22 CN disclosed
EP-0831769-B2 NOVEL USES FOR THYROID HORMONES OR THYROID HORMONE-LIKE COMPOUNDS LAVIN DR THOMAS N (US) 2008-07-23 EP disclosed
US-4910305-A Containing a protected 4-hydroxyphenyl SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) 1990-03-20 US disclosed
US-4766121-A NOT AFFECTING THE HEART SMITH KLINE & FRENCH LABORATORIES LTD. (GB) 1988-08-23 US disclosed
CN-86100894-A Process for the preparation of compounds 1986-09-03 CN disclosed