Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2A6 | P11509 | 1/20 | 0.56 |
| ▸ | ATP6V1B1 | P15313 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | IDO1 | P14902 | 1/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | FLT3 | P36888 | 1/20 | 0.47 |
| ▸ | DAO | P14920 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.44 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.44 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3220733 | 1.00 | CYP2A6 (0.56) | CYP2A6ATP6V1B1MAPK1MAPTIDO1 | |
| SCHEMBL15475156 | 0.93 | ATP6V1B1 (0.52) | CYP2A6ATP6V1B1MAPK1MAPTIDO1 | |
| SCHEMBL15475158 | 0.93 | ATP6V1B1 (0.52) | CYP2A6ATP6V1B1MAPK1MAPTIDO1 | |
| SCHEMBL14386994 | 0.89 | CYP2A6 (0.51) | CYP2A6ATP6V1B1MAPK1MAPTIDO1 | |
| SCHEMBL29455098 | 0.85 | CYP2A6 (0.58) | CYP2A6ATP6V1B1MAPK1MAPTIDO1 | |
| SCHEMBL245110 | 0.85 | CYP2A6 (0.58) | CYP2A6ATP6V1B1MAPK1MAPTIDO1 | |
| SCHEMBL30640889 | 0.85 | CYP2A6 (0.58) | CYP2A6ATP6V1B1MAPK1MAPTIDO1 | |
| SCHEMBL179872 | 0.85 | CYP2A6 (0.58) | CYP2A6ATP6V1B1MAPK1MAPTIDO1 | |
| SCHEMBL31447975 | 0.83 | CYP2A6 (0.56) | CYP2A6ATP6V1B1MAPK1MAPTIDO1 | |
| SCHEMBL13229465 | 0.83 | CYP2A6 (0.56) | CYP2A6ATP6V1B1MAPK1MAPTIDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8962674-B2 | Curcumin derivative | TOKYO INSTITUTE OF TECHNOLOGY (JP) | 2015-02-24 | — | — | US | disclosed |
| US-20100048901-A1 | NOVEL CURCUMIN DERIVATIVE | TOKYO INSTITUTE OF TECHNOLOGY (JP) | 2010-02-25 | — | — | US | disclosed |
| EP-2123637-A1 | NOVEL CURCUMIN DERIVATIVE | Tokyo Institute of Technology (JP) | 2009-11-25 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100048901-A1 | NOVEL CURCUMIN DERIVATIVE | BACE1, APP, BACE2 | CYP2A6 3242/4885ATP6V1B1 4220/4885MAPK1 921/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.