Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Adipic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | FABP4 | P15090 | 1/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.40 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL284479 | 0.84 | MKNK1 (0.49) | KMT2AMEN1SMN1; SMN2NPC1RAB9A | |
| Hydrochloric Acid SCHEMBL27585323 | 0.82 | MKNK1 (0.47) | KMT2AMEN1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL14032006 | 0.81 | KMT2A (0.62) | TSHRKMT2AMEN1GAASMN1; SMN2 | |
| Adipic Acid SCHEMBL4456880 | 0.80 | KMT2A (0.56) | TSHRKMT2AMEN1SMN1; SMN2NPC1 | |
| Adipic Acid SCHEMBL27952557 | 0.79 | TSHR (0.64) | TSHRKMT2AMEN1GAASMN1; SMN2 | |
| SCHEMBL5679029 | 0.78 | PARP1 (0.50) | SMN1; SMN2NPC1RAB9AALDH1A1NFE2L2 | |
| SCHEMBL10618681 | 0.77 | SMN1; SMN2 (0.44) | KMT2AMEN1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL3519350 | 0.76 | KMT2A (0.74) | TSHRKMT2AMEN1GAASMN1; SMN2 | |
| SCHEMBL31661658 | 0.76 | KMT2A (0.74) | TSHRKMT2AMEN1GAASMN1; SMN2 | |
| SCHEMBL18675955 | 0.75 | TSHR (0.59) | TSHRKMT2AMEN1GAASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100057052-A1 | Medical Catheter Tube | KANEKA CORPORATION (JP) | 2010-03-04 | — | — | US | disclosed |
| EP-2080535-A1 | CATHETER TUBE FOR MEDICAL USE | Kaneka Corporation (JP) | 2009-07-22 | — | — | EP | disclosed |