Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.49 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.49 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.47 |
| ▸ | NNMT | P40261 | 2/20 | 0.47 |
| ▸ | PARP1 | P09874 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | TNF | P01375 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.44 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.44 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.44 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.44 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL27585323 | 0.98 | MKNK1 (0.47) | MKNK1MKNK2NFE2L2NNMTPARP1 | |
| SCHEMBL5679029 | 0.92 | PARP1 (0.50) | MKNK1MKNK2NFE2L2NNMTPARP1 | |
| Adipic Acid SCHEMBL3220731 | 0.84 | TSHR (0.50) | MKNK1MKNK2NFE2L2SMN1; SMN2KMT2A | |
| SCHEMBL23846347 | 0.84 | MKNK1 (0.59) | MKNK1MKNK2NNMTPARP1 | |
| SCHEMBL7837115 | 0.83 | NFE2L2 (0.46) | NFE2L2KMT2AHSD11B1NPC1RAB9A | |
| SCHEMBL11379714 | 0.83 | NFE2L2 (0.49) | NFE2L2SMN1; SMN2KMT2AHTTHSD11B1 | |
| SCHEMBL1804232 | 0.82 | PARP1 (0.47) | NNMTPARP1SMN1; SMN2TDP1NPC1 | |
| SCHEMBL2128609 | 0.82 | PARP1 (0.52) | MKNK1MKNK2NNMTPARP1SMN1; SMN2 | |
| SCHEMBL1003845 | 0.82 | MEN1 (0.53) | PARP1SMN1; SMN2KMT2ATDP1NPC1 | |
| SCHEMBL9420260 | 0.81 | NFE2L2 (0.55) | NFE2L2SMN1; SMN2KMT2AHTTHSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 244 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107102082-B | Method for determining residual quantity of amitraz and metabolite thereof in royal jelly by liquid chromatography-mass spectrometry/mass spectrometry | 浙江省检验检疫科学技术研究院 | 2019-12-17 | — | — | CN | claimed |
| EP-1773768-B1 | PYRROLE DERIVATIVES AS PHARMACEUTICAL AGENTS | EXELIXIS INC (US) | 2018-08-22 | — | — | EP | claimed |
| EP-2292625-B1 | SUBSTITUTED SPIRO COMPOUNDS AND THEIR USE FOR PRODUCING PAIN-RELIEF MEDICAMENTS | GRUENENTHAL GMBH (DE) | 2013-12-25 | — | — | EP | claimed |
| EP-1648874-B1 | PIPERAZINE DERIVATIVES AND THEIR USE AS THERAPEUTIC AGENTS | XENON PHARMACEUTICALS INC (CA) | 2011-10-05 | — | — | EP | claimed |
| EP-1846035-B1 | COMBINATION THERAPY | XENON PHARMACEUTICALS INC (CA) | 2011-09-21 | — | — | EP | claimed |
| US-20100222330-A1 | New Compounds | BIOVITRUM AB (SE) | 2010-09-02 | — | — | US | claimed |
| US-20100056460-A1 | COMBINATION OF ORGANIC COMPOUNDS | ALI MOHAMMED A | 2010-03-04 | — | — | US | claimed |
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | claimed |
| US-7572787-B2 | Substituted naphthalene sulfonamides | BIOVITRUM AB (SE) | 2009-08-11 | — | — | US | claimed |
| US-20090131447-A1 | COMBINATION THERAPY | XENON PHARMACEUTICALS INC. (CA) | 2009-05-21 | — | — | US | claimed |
| WO-2002100822-A1 | SUBSTITUTED SULFONAMIDE COMPOUNDS, PROCESS FOR THEIR USE AS MEDICAMENT FOR THE TREATMENT OF CNS DISORDERS, OBESITY AND TYPE II DIABETES | BIOVITRUM AB (SE) | 2002-12-19 | — | — | WO | claimed |
| US-20020025977-A1 | N-phenyl benzimidazolecarboxamide and N-phenyl indolecarboxamide derivatives | NEUROGEN CORPORATION | 2002-02-28 | — | — | US | claimed |
| EP-1150565-A1 | THIAZOLE DERIVATIVES AND COMBINATORIAL LIBRARIES THEREOF | LION bioscience AG (DE) | 2001-11-07 | — | — | EP | claimed |
| EP-1126833-A2 | OXADIAZOLE, THIADIAZOLE AND TRIAZOLE DERIVATIVES AND COMBINATORIAL LIBRARIES THEREOF | TREGA BIOSCIENCES, INC. (US) | 2001-08-29 | — | — | EP | claimed |
| WO-2000045635-A1 | THIAZOLE DERIVATIVES AND COMBINATORIAL LIBRARIES THEREOF | LION BIOSCIENCE AG (DE) | 2000-08-10 | — | — | WO | claimed |
| WO-2000025768-A1 | OXADIAZOLE, THIADIAZOLE AND TRIAZOLE DERIVATIVES AND COMBINATORIAL LIBRARIES THEREOF | TREGA BIOSCIENCES, INC. (US) | 2000-05-11 | — | — | WO | claimed |
| EP-0550557-B1 | DETERGENT CONTAINING ALKYL SULFATE AND POLYHYDROXY FATTY ACID AMIDE SURFACTANTS | PROCTER & GAMBLE (US) | 1996-03-20 | — | — | EP | claimed |
| EP-0670874-A1 | LOW SUDSING POLYHYDROXY FATTY ACID AMIDE DETERGENTS | THE PROCTER & GAMBLE COMPANY (US) | 1995-09-13 | — | — | EP | claimed |
| WO-1994012597-A1 | LOW SUDSING POLYHYDROXY FATTY ACID AMIDE DETERGENTS | THE PROCTER & GAMBLE COMPANY (US) | 1994-06-09 | — | — | WO | claimed |
| US-4942232-A | FOR PRINTING AND DYEING CELLULOSE FIBERS | BASF AKTIENGESELLSCHAFT (DE) | 1990-07-17 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020025977-A1 | N-phenyl benzimidazolecarboxamide and N-phenyl indolecarboxamide derivatives | CRHR1, CRHR2, HTR2C | MKNK1 3664/4885MKNK2 3810/4885NFE2L2 1289/4885 |
| US-20100056460-A1 | COMBINATION OF ORGANIC COMPOUNDS | REN, IAPP, ACE | MKNK1 1643/4885MKNK2 2190/4885NFE2L2 2111/4885 |
| US-20090131447-A1 | COMBINATION THERAPY | SCD, SCD5, ARG1 | MKNK1 3611/4885MKNK2 3520/4885NFE2L2 4125/4885 |
| US-20100222330-A1 | New Compounds | SULT2A1, GPR119, STS | MKNK1 2907/4885MKNK2 2301/4885NFE2L2 597/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.