SCHEMBL3220810

SCHEMBL3220810

O=C(OCc1cc(=O)c(O)co1)c1ccccc1

nearest known ligand 0.82

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
DAO P14920 4/20 0.63
TYR P14679 2/20 0.57
POLB P06746 1/20 0.57
GAA P10253 1/20 0.57
IDH1 O75874 1/20 0.56
ELANE P08246 1/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7558334 0.93 POLB (0.63) DAOTYRPOLBGAAELANE
SCHEMBL7550581 0.91 POLB (0.60) DAOTYRPOLBGAAELANE
SCHEMBL361178 0.90 POLB (0.61) DAOTYRPOLBGAAELANE
SCHEMBL360885 0.89 POLB (0.57) DAOTYRPOLBGAAELANE
SCHEMBL361245 0.84 DAO (0.58) DAOTYRIDH1ELANE
SCHEMBL361231 0.84 POLB (0.61) DAOTYRPOLBGAAELANE
SCHEMBL7554264 0.82 DAO (0.54) DAOTYRPOLBGAAELANE
SCHEMBL359337 0.80 DAO (0.52) DAOTYRPOLBGAAELANE
SCHEMBL7551138 0.79 POLB (0.53) DAOTYRPOLBGAAELANE
SCHEMBL9085769 0.79 SERPINE1 (0.56) DAOTYRELANE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0419901-A1 Endermic preparation for external application Sansho Seiyaku Co., Ltd. (JP) 1991-04-03 EP claimed
JP-62178506-A None JP disclosed
US-20160074315-A1 TOPICAL COSMETIC SKIN LIGHTENING COMPOSITIONS AND METHODS OF USE THEREOF STIEFEL LABORATORIES, INC. 2016-03-17 US disclosed
EP-2219600-A1 TOPICAL COSMETIC SKIN LIGHTENING COMPOSITIONS AND METHODS OF USE THEREOF STIEFEL LABORATORIES, INC. (US) 2010-08-25 EP disclosed
US-20100034757-A1 EXTRACT POWDER OF INDIGO PLANT, AND ITS PREPARATION AND USES KABUSHIKI KAISHA HAYASHIBARA SEIBUTSU KAGAKU KENKYUJO (JP) 2010-02-11 US disclosed
US-20090263339-A1 AGENT FOR EXTERNAL APPLICATION TO THE SKIN KABUSHIKI KAISHA HAYASHIBARA SEIBUTSU KAGAKU KENKY (JP) 2009-10-22 US disclosed
EP-2087903-A1 EXTRACT POWDER OF INDIGO-CONTAINING PLANT, METHOD FOR PRODUCTION THEREOF, AND USE THEREOF Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo (JP) 2009-08-12 EP disclosed
WO-2009067095-A1 TOPICAL COSMETIC SKIN LIGHTENING COMPOSITIONS AND METHODS OF USE THEREOF STIEFEL LABORATORIES, INC. (US) 2009-05-28 WO disclosed
EP-1602354-B1 Use of polyglutamic acid or its salts MEIJI SEIKA KAISHA (JP) 2008-11-05 EP disclosed
EP-1604647-B1 Cosmetic composition containing polyorganosiloxane-containing epsilon-polylysine polymer, and polyhydric alcohol, and production thereof CHISSO CORP (JP) 2008-05-07 EP disclosed
EP-1894558-A1 AGENT FOR EXTERNAL APPLICATION TO THE SKIN Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo (JP) 2008-03-05 EP disclosed
US-20060165636-A1 Hair treatment composition and hair cosmetic for damaged hair MEIJI SEIKA KAISHA, LTD. (JP) 2006-07-27 US disclosed
US-20060018867-A1 Cosmetic composition and production thereof ICHIMARU PHARCOS CO., LTD 2006-01-26 US disclosed
EP-1604647-A1 Cosmetic composition containing polyorganosiloxane-containing epsilon-polylysine polymer, and polyhydric alcohol, and production thereof Ichimaru Pharcos Co., Ltd. (JP) 2005-12-14 EP disclosed
EP-1602354-A1 HAIR TREATMENT COMPOSITION AND HAIR COSMETIC FOR DAMAGED HAIR Meiji Seika Kaisha, Ltd. (JP) 2005-12-07 EP disclosed
EP-0419901-A1 Endermic preparation for external application Sansho Seiyaku Co., Ltd. (JP) 1991-04-03 EP disclosed
JP-S62178506-A MELANIN FORMATION SUPPRESSING EXTERNAL PREPARATION SANSHO SEIYAKU KK 1987-08-05 JP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060165636-A1 Hair treatment composition and hair cosmetic for damaged hair CUTA, COL14A1, PRKDC DAO 1824/4885TYR 46/4885POLB 242/4885
US-20060018867-A1 Cosmetic composition and production thereof CUTA, PARG, TYR DAO 117/4885TYR 3/4885POLB 27/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.