Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.63 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.63 |
| ▸ | BACE1 | P56817 | 4/20 | 0.61 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.41 |
| ▸ | ALDH1A3 | P47895 | 1/20 | 0.41 |
| ▸ | RXRA | P19793 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 6/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.41 |
| ▸ | MEN1 | O00255 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.40 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | CRHBP | P24387 | 1/20 | 0.37 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3208275 | 0.84 | BACE1 (0.84) | ALDH1A1L3MBTL1BACE1RXRAMAPT | |
| SCHEMBL3208287 | 0.84 | BACE1 (0.84) | ALDH1A1L3MBTL1BACE1RXRAMAPT | |
| SCHEMBL28370301 | 0.83 | ALDH1A1 (0.67) | ALDH1A1L3MBTL1BACE1ALDH3A1ALDH1A3 | |
| SCHEMBL5146907 | 0.83 | ALDH1A1 (0.74) | ALDH1A1L3MBTL1BACE1ALDH3A1ALDH1A3 | |
| SCHEMBL11864011 | 0.81 | ALDH1A1 (0.63) | ALDH1A1L3MBTL1BACE1ALDH3A1ALDH1A3 | |
| SCHEMBL3224984 | 0.81 | ALDH1A1 (0.67) | ALDH1A1L3MBTL1BACE1ALDH3A1ALDH1A3 | |
| SCHEMBL9361815 | 0.80 | ALDH1A1 (0.70) | ALDH1A1L3MBTL1BACE1ALDH3A1ALDH1A3 | |
| SCHEMBL14712980 | 0.80 | ALDH1A1 (0.70) | ALDH1A1L3MBTL1BACE1ALDH3A1ALDH1A3 | |
| SCHEMBL11420383 | 0.79 | ALDH1A1 (0.60) | ALDH1A1L3MBTL1BACE1ALDH3A1ALDH1A3 | |
| SCHEMBL7037114 | 0.79 | ALDH1A1 (0.68) | ALDH1A1L3MBTL1BACE1ALDH3A1ALDH1A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8962674-B2 | Curcumin derivative | TOKYO INSTITUTE OF TECHNOLOGY (JP) | 2015-02-24 | — | — | US | disclosed |
| US-20100048901-A1 | NOVEL CURCUMIN DERIVATIVE | TOKYO INSTITUTE OF TECHNOLOGY (JP) | 2010-02-25 | — | — | US | disclosed |
| EP-2123637-A1 | NOVEL CURCUMIN DERIVATIVE | Tokyo Institute of Technology (JP) | 2009-11-25 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100048901-A1 | NOVEL CURCUMIN DERIVATIVE | BACE1, APP, BACE2 | ALDH1A1 253/4885L3MBTL1 2164/4885BACE1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.