Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Diphenhydramine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 known ✓ | P35367 | 2/20 | 0.66 |
| ▸ | LMNA | P02545 | 8/20 | 0.80 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.80 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.66 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.66 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.66 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.66 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.66 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.66 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.66 |
| ▸ | DRD3 | P35462 | 3/20 | 0.66 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.66 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.66 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.66 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.66 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.66 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.66 |
| ▸ | HRH2 | P25021 | 2/20 | 0.66 |
| ▸ | HTR2A | P28223 | 2/20 | 0.66 |
| ▸ | HTR2C | P28335 | 2/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Diphenhydramine SCHEMBL5678067 | 0.99 | LMNA (0.79) | LMNAKDM4ECYP2D6CHRM2ADRA2A | |
| Diphenhydramine SCHEMBL7914760 | 0.99 | LMNA (0.79) | LMNAKDM4ECYP2D6CHRM2ADRA2A | |
| Orphenadrine SCHEMBL4451316 | 0.90 | KDM4E (1.00) | LMNAKDM4ECYP2D6CHRM2ADRA2A | |
| Orphenadrine SCHEMBL29369316 | 0.90 | KDM4E (1.00) | LMNAKDM4ECYP2D6CHRM2ADRA2A | |
| Orphenadrine SCHEMBL119470 | 0.90 | KDM4E (1.00) | LMNAKDM4ECYP2D6CHRM2ADRA2A | |
| Citric Acid SCHEMBL5924571 | 0.88 | LMNA (0.65) | LMNAKDM4ECYP2D6CHRM2ADRA2A | |
| Citric Acid SCHEMBL2791723 | 0.87 | LMNA (0.64) | LMNAKDM4ECYP2D6CHRM2ADRA2A | |
| Cizolirtine SCHEMBL2791717 | 0.86 | LMNA (0.65) | LMNAKDM4ECYP2D6CHRM2ADRA2A | |
| Cizolirtine SCHEMBL1649170 | 0.86 | LMNA (0.65) | LMNAKDM4ECYP2D6CHRM2ADRA2A | |
| Diphenhydramine SCHEMBL29362028 | 0.85 | LMNA (0.62) | LMNAKDM4ECYP2D6CHRM2ADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1751 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119707718-A | Process for removing specific impurity of diphenhydramine citrate | 植恩生物技术股份有限公司 | 2025-03-28 | — | — | CN | claimed |
| EP-3793518-B1 | AN ORAL TABLET FOR TASTE MASKING OF ACTIVE INGREDIENTS COMPRISING NON-DIRECTLY COMPRESSIBLE SUGAR ALCOHOL PARTICLES | FERTIN PHARMA AS (DK) | 2025-03-26 | — | — | EP | claimed |
| US-20250009663-A1 | Mouthwash For Oral Care Benefits | FERTIN PHARMA A/S (DK) | 2025-01-09 | — | — | US | claimed |
| EP-4088716-B1 | AN ORAL TABLET FOR INDUCED SALIVA GENERATION | FERTIN PHARMA AS (DK) | 2024-10-16 | — | — | EP | claimed |
| US-12109312-B2 | Oral tablet for taste masking of active ingredients | FERTIN PHARMA A/S (DK) | 2024-10-08 | — | — | US | claimed |
| US-20240282425-A1 | AUTHENTICATION METHODS AND SYSTEMS FOR DISPENSED PRESCRIPTIONS | LOW GORDON KEITH (US) | 2024-08-22 | — | — | US | claimed |
| US-20240189227-A1 | EASY CHEW FORMULATIONS | HALEON US HOLDINGS LLC | 2024-06-13 | — | — | US | claimed |
| EP-4333895-A1 | EASY CHEW FORMULATIONS | Haleon US IP LLC (US) | 2024-03-13 | — | — | EP | claimed |
| EP-4327797-A2 | MULTI PHASE SOFT GEL CAPSULES, APPARATUS AND METHOD THEREOF | Catalent Ontario Limited (CA) | 2024-02-28 | — | — | EP | claimed |
| US-20240041777-A1 | PHARMACEUTICAL CAPSULE CONTAINING AT LEAST TWO TABLETS | RB HEALTH US LLC (US) | 2024-02-08 | — | — | US | claimed |
| EP-0746342-A1 | BIODEGRADABLE CONTROLLED RELEASE MELT-SPUN DELIVERY SYSTEM | FUISZ TECHNOLOGIES LTD. (US) | 1996-12-11 | — | — | EP | claimed |
| US-5518730-A | Biodegradable controlled release flash flow melt-spun delivery system | FUISZ TECHNOLOGIES LTD. (US) | 1996-05-21 | — | — | US | claimed |
| EP-0746342-A4 | BIODEGRADABLE CONTROLLED RELEASE MELT-SPUN DELIVERY SYSTEM | FUISZ TECHNOLOGIES LTD (US) | 1996-01-11 | — | — | EP | claimed |
| EP-0608320-A1 | ENHANCED SKIN PENETRATION SYSTEM FOR IMPROVED TOPICAL DELIVERY OF DRUGS | RICHARDSON-VICKS, INC. (US) | 1994-08-03 | — | — | EP | claimed |
| EP-0608322-A1 | ENHANCED SKIN PENETRATION SYSTEM FOR IMPROVED TOPICAL DELIVERY OF DRUGS | RICHARDSON-VICKS, INC. (US) | 1994-08-03 | — | — | EP | claimed |
| WO-1993024154-A1 | BIODEGRADABLE CONTROLLED RELEASE MELT-SPUN DELIVERY SYSTEM | FUISZ TECHNOLOGIES, LTD. (US) | 1993-12-09 | — | — | WO | claimed |
| WO-1993007902-A1 | ENHANCED SKIN PENETRATION SYSTEM FOR IMPROVED TOPICAL DELIVERY OF DRUGS | RICHARDSON-VICKS, INC. (US) | 1993-04-29 | — | — | WO | claimed |
| WO-1993007903-A1 | ENHANCED SKIN PENETRATION SYSTEM FOR IMPROVED TOPICAL DELIVERY OF DRUGS | RICHARDSON-VICKS, INC. (US) | 1993-04-29 | — | — | WO | claimed |
| EP-0351897-A2 | Skin penetration system for salts of amine-functional drugs | THE PROCTER & GAMBLE COMPANY (US) | 1990-01-24 | — | — | EP | claimed |
| EP-0194547-A2 | Stable acetylsalicylic acid and diphenhydramine citrate effervescent composition | MILES LABORATORIES, INC. (US) | 1986-09-17 | — | — | EP | claimed |