Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Diphenhydramine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 known ✓ | P35367 | 2/20 | 0.64 |
| ▸ | LMNA | P02545 | 8/20 | 0.79 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.79 |
| ▸ | PMP22 | Q01453 | 3/20 | 0.67 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.67 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.64 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.64 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.64 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.64 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.64 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.64 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.64 |
| ▸ | DRD3 | P35462 | 3/20 | 0.64 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.64 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.64 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.64 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.64 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.64 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Diphenhydramine SCHEMBL5678067 | 1.00 | LMNA (0.79) | LMNAKDM4EPMP22MAPK1SMN1; SMN2 | |
| Diphenhydramine SCHEMBL322306 | 0.99 | LMNA (0.80) | LMNAKDM4EPMP22MAPK1SMN1; SMN2 | |
| Orphenadrine SCHEMBL119470 | 0.88 | KDM4E (1.00) | LMNAKDM4EPMP22MAPK1SMN1; SMN2 | |
| Orphenadrine SCHEMBL29369316 | 0.88 | KDM4E (1.00) | LMNAKDM4EPMP22MAPK1SMN1; SMN2 | |
| Orphenadrine SCHEMBL4451316 | 0.88 | KDM4E (1.00) | LMNAKDM4EPMP22MAPK1SMN1; SMN2 | |
| Citric Acid SCHEMBL5924571 | 0.87 | LMNA (0.65) | LMNAKDM4EPMP22MAPK1SMN1; SMN2 | |
| Citric Acid SCHEMBL2791723 | 0.86 | LMNA (0.64) | LMNAKDM4EPMP22MAPK1SMN1; SMN2 | |
| Cizolirtine SCHEMBL2791717 | 0.85 | LMNA (0.65) | LMNAKDM4EPMP22MAPK1SMN1; SMN2 | |
| Cizolirtine SCHEMBL1649170 | 0.85 | LMNA (0.65) | LMNAKDM4EPMP22MAPK1SMN1; SMN2 | |
| Diphenhydramine SCHEMBL29362028 | 0.84 | LMNA (0.62) | LMNAKDM4EPMP22MAPK1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6214386-B1 | DRUG DELIVERY; NON TIME-RELEASE FORMULATION | RECORDATI, S.A. | 2001-04-10 | — | — | US | disclosed |