Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMO | O15229 | 3/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | KDM4C | Q9H3R0 | 4/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.53 |
| ▸ | KDM5A | P29375 | 3/20 | 0.53 |
| ▸ | KDM5B | Q9UGL1 | 3/20 | 0.53 |
| ▸ | KDM4A | O75164 | 2/20 | 0.53 |
| ▸ | ALKBH5 | Q6P6C2 | 2/20 | 0.53 |
| ▸ | FTO | Q9C0B1 | 2/20 | 0.53 |
| ▸ | KDM6B | O15054 | 1/20 | 0.53 |
| ▸ | TET3 | O43151 | 1/20 | 0.53 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | KDM5C | P41229 | 1/20 | 0.53 |
| ▸ | ASPH | Q12797 | 1/20 | 0.53 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.53 |
| ▸ | TET2 | Q6N021 | 1/20 | 0.53 |
| ▸ | KDM7A | Q6ZMT4 | 1/20 | 0.53 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.53 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7513922 | 0.86 | KMO (0.71) | KMOALDH1A1KDM4CKDM4EKDM5A | |
| SCHEMBL30800092 | 0.86 | KMO (0.71) | KMOALDH1A1KDM4CKDM4EKDM5A | |
| SCHEMBL27772527 | 0.84 | MKNK1 (0.51) | KMOMCL1FDPSMAP4K4DHODH | |
| SCHEMBL28284992 | 0.83 | KDM4E (0.66) | KMOALDH1A1KDM4CKDM4EKDM5A | |
| SCHEMBL725162 | 0.82 | KMO (0.62) | KMOALDH1A1KDM4CKDM4EKDM5A | |
| SCHEMBL16673126 | 0.82 | KMO (0.62) | KMOALDH1A1KDM4CKDM4EKDM5A | |
| SCHEMBL2558040 | 0.82 | KMO (0.58) | KMOALDH1A1KDM4CKDM4EKDM5A | |
| SCHEMBL23201148 | 0.82 | KMO (0.65) | KMOALDH1A1KDM4CKDM4EKDM5A | |
| SCHEMBL30882313 | 0.82 | KMO (0.65) | KMOALDH1A1KDM4CKDM4EKDM5A | |
| SCHEMBL24572141 | 0.81 | KMO (0.62) | KMOALDH1A1KDM4CKDM4EKDM5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7683097-B2 | Topoisomerase inhibitors | Propharmacon Inc. (US) | 2010-03-23 | — | — | US | disclosed |
| US-20070004701-A1 | Topoisomerase inhibitors | PROPHARMACON, INC. (US) | 2007-01-04 | — | — | US | disclosed |
| WO-2006022955-A2 | TOPOISOMERASE INHIBITORS | PROPHARMACON, INC. (US) | 2006-03-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070004701-A1 | Topoisomerase inhibitors | TOP1, TOP2A, TOP2B | KMO 3110/4885ALDH1A1 3255/4885KDM4C 997/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.