Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | TDP2 | O95551 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 3/20 | 0.37 |
| ▸ | CASP6 | P55212 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
| ▸ | CCR6 | P51684 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | APAF1 | O14727 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | HTR7 | P34969 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16110538 | 0.89 | MEN1 (0.46) | MEN1KMT2AHPGDTDP2GAA | |
| SCHEMBL16110144 | 0.88 | MEN1 (0.52) | MEN1KMT2AHPGDGAACASP6 | |
| SCHEMBL16110129 | 0.84 | HPGD (0.42) | MEN1KMT2AHPGDTDP2GAA | |
| SCHEMBL16110147 | 0.83 | HPGD (0.59) | MEN1KMT2AHPGDTDP2GAA | |
| SCHEMBL13427270 | 0.82 | MEN1 (0.46) | MEN1KMT2AHPGDGAACASP6 | |
| SCHEMBL16110253 | 0.82 | MEN1 (0.60) | THRBMEN1KMT2AHPGDALDH1A1 | |
| SCHEMBL14967395 | 0.78 | MAPT (0.51) | MEN1KMT2AHPGDGAAALDH1A1 | |
| SCHEMBL16110125 | 0.75 | HPGD (0.49) | MEN1KMT2AHPGDTDP2GAA | |
| SCHEMBL5785720 | 0.71 | NOTUM (0.56) | TDP2ALDH1A1KDM4EL3MBTL1NOTUM | |
| SCHEMBL7009115 | 0.70 | HPGD (0.62) | MEN1KMT2AHPGDGAACASP6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11413274-B2 | Methods and compositions associated with the granulocyte colony-stimulating factor receptor | LIGAND PHARMACEUTICALS, INC. (US) | 2022-08-16 | — | — | US | disclosed |
| US-20210046045-A1 | METHODS AND COMPOSITIONS ASSOCIATED WITH THE GRANULOCYTE COLONY-STIMULATING FACTOR RECEPTOR | CITIBANK, N.A., AS ADMINISTRATIVE AGENT | 2021-02-18 | — | — | US | disclosed |
| US-10736875-B2 | Methods and compositions associated with the granulocyte colony-stimulating factor receptor | LIGAND PHARMACEUTICALS, INC. (US) | 2020-08-11 | — | — | US | disclosed |
| US-20180369197-A1 | METHODS AND COMPOSITIONS ASSOCIATED WITH THE GRANULOCYTE COLONY-STIMULATING FACTOR RECEPTOR | CITIBANK, N.A., AS ADMINISTRATIVE AGENT | 2018-12-27 | — | — | US | disclosed |
| US-10111859-B2 | Methods and compositions associated with the granulocyte colony-stimulating factor receptor | LIGAND PHARMACEUTICALS, INC. (US) | 2018-10-30 | — | — | US | disclosed |
| EP-2780322-B1 | METHODS AND COMPOSITIONS ASSOCIATED WITH THE GRANULOCYTE COLONY-STIMULATING FACTOR RECEPTOR | LIGAND PHARM INC (US) | 2018-05-16 | — | — | EP | disclosed |
| US-20160374989-A1 | METHODS AND COMPOSITIONS ASSOCIATED WITH THE GRANULOCYTE COLONY-STIMULATING FACTOR RECEPTOR | CITIBANK, N.A., AS ADMINISTRATIVE AGENT | 2016-12-29 | — | — | US | disclosed |
| US-9492430-B2 | Methods and compositions associated with the granulocyte colony-stimulating factor receptor | LIGAND PHARMACEUTICALS, INCORPORATED (US) | 2016-11-15 | — | — | US | disclosed |
| US-20140296292-A1 | METHODS AND COMPOSITIONS ASSOCIATED WITH THE GRANULOCYTE COLONY-STIMULATING FACTOR RECEPTOR | CITIBANK, N.A., AS ADMINISTRATIVE AGENT | 2014-10-02 | — | — | US | disclosed |
| EP-2780322-A1 | METHODS AND COMPOSITIONS ASSOCIATED WITH THE GRANULOCYTE COLONY-STIMULATING FACTOR RECEPTOR | Ligand Pharmaceuticals Inc. (US) | 2014-09-24 | — | — | EP | disclosed |
| WO-2013074459-A1 | METHODS AND COMPOSITIONS ASSOCIATED WITH THE GRANULOCYTE COLONY-STIMULATING FACTOR RECEPTOR | LIGAND PHARMACEUTICALS, INC. (US) | 2013-05-23 | — | — | WO | disclosed |
| US-20100063301-A1 | SYNTHESIS OF THROMBOPOIETIN ACTIVITY MODULATING COMPOUNDS | LIGAND PHARMACEUTICALS INC (US) | 2010-03-11 | — | — | US | disclosed |
| US-20100063301-A1 | SYNTHESIS OF THROMBOPOIETIN ACTIVITY MODULATING COMPOUNDS | LIGAND PHARMACEUTICALS INC (US) | 2010-03-11 | — | — | US | disclosed |
| US-20100063301-A1 | SYNTHESIS OF THROMBOPOIETIN ACTIVITY MODULATING COMPOUNDS | LIGAND PHARMACEUTICALS INC (US) | 2010-03-11 | — | — | US | disclosed |
| CN-101437792-A | Synthesis of thrombopoietin activity modulating compounds | LIGAND PHARM INC (US) | 2009-05-20 | — | — | CN | disclosed |
| EP-2001845-A2 | SYNTHESIS OF THROMBOPOIETIN ACTIVITY MODULATING COMPOUNDS | LIGAND PHARMACEUTICALS, INC. (US) | 2008-12-17 | — | — | EP | disclosed |
| WO-2007106564-A2 | SYNTHESIS OF THROMBOPOIETIN ACTIVITY MODULATING COMPOUNDS | LIGAND PHARMACEUTICALS INC. (US) | 2007-09-20 | — | — | WO | disclosed |
| WO-2007106564-A2 | SYNTHESIS OF THROMBOPOIETIN ACTIVITY MODULATING COMPOUNDS | LIGAND PHARMACEUTICALS INC. (US) | 2007-09-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180369197-A1 | METHODS AND COMPOSITIONS ASSOCIATED WITH THE GRANULOCYTE COLONY-STIMULATING FACTOR RECEPTOR | CSF3R, GMFG, CSF1R | THRB 1986/4885MEN1 2845/4885KMT2A 2705/4885 |
| US-20100063301-A1 | SYNTHESIS OF THROMBOPOIETIN ACTIVITY MODULATING COMPOUNDS | MPL, THPO, TBXAS1 | THRB 692/4885MEN1 1398/4885KMT2A 4074/4885 |
| US-20160374989-A1 | METHODS AND COMPOSITIONS ASSOCIATED WITH THE GRANULOCYTE COLONY-STIMULATING FACTOR RECEPTOR | CSF3R, GMFG, CSF1R | THRB 1986/4885MEN1 2845/4885KMT2A 2705/4885 |
| US-20140296292-A1 | METHODS AND COMPOSITIONS ASSOCIATED WITH THE GRANULOCYTE COLONY-STIMULATING FACTOR RECEPTOR | CSF3R, GMFG, CSF1R | THRB 1986/4885MEN1 2845/4885KMT2A 2705/4885 |
| US-11413274-B2 | Methods and compositions associated with the granulocyte colony-stimulating factor receptor | CSF3R, GMFG, CSF1R | THRB 1986/4885MEN1 2845/4885KMT2A 2705/4885 |
| US-10111859-B2 | Methods and compositions associated with the granulocyte colony-stimulating factor receptor | CSF3R, GMFG, CSF1R | THRB 1986/4885MEN1 2845/4885KMT2A 2705/4885 |
| US-20210046045-A1 | METHODS AND COMPOSITIONS ASSOCIATED WITH THE GRANULOCYTE COLONY-STIMULATING FACTOR RECEPTOR | CSF3R, GMFG, CSF1R | THRB 1986/4885MEN1 2845/4885KMT2A 2705/4885 |
| US-10736875-B2 | Methods and compositions associated with the granulocyte colony-stimulating factor receptor | CSF3R, GMFG, CSF1R | THRB 1986/4885MEN1 2845/4885KMT2A 2705/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.