Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM3 | P20309 | 11/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 11/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 11/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 10/20 | 0.39 |
| ▸ | CHRM5 | P08912 | 10/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HRH1 | P35367 | 1/20 | 0.35 |
| ▸ | SCN1A | P35498 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.35 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3223958 | 1.00 | CHRM3 (0.40) | CHRM3CHRM2CHRM1CHRM4CHRM5 | |
| SCHEMBL14101280 | 0.89 | CHRM3 (0.38) | CHRM3CHRM2CHRM1CHRM4CHRM5 | |
| SCHEMBL1109883 | 0.88 | CHRM3 (0.41) | CHRM3CHRM2CHRM1CHRM4CHRM5 | |
| SCHEMBL4785975 | 0.88 | CHRM3 (0.41) | CHRM3CHRM2CHRM1CHRM4CHRM5 | |
| SCHEMBL4776914 | 0.87 | CHRM3 (0.40) | CHRM3CHRM2CHRM1CHRM4CHRM5 | |
| SCHEMBL3227714 | 0.86 | SIGMAR1 (0.41) | CHRM3CHRM2CHRM1CHRM4CHRM5 | |
| SCHEMBL3227705 | 0.86 | SIGMAR1 (0.41) | CHRM3CHRM2CHRM1CHRM4CHRM5 | |
| SCHEMBL1109823 | 0.85 | CHRM3 (0.40) | CHRM3CHRM2CHRM1CHRM4CHRM5 | |
| SCHEMBL3221153 | 0.85 | CHRM3 (0.40) | CHRM3CHRM2CHRM1CHRM4CHRM5 | |
| SCHEMBL27774376 | 0.85 | CHRM3 (0.40) | CHRM3CHRM2CHRM1CHRM4CHRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010015792-A1 | NITROGEN CONTAINING HETEROCYCLIC COMPOUNDS USEFUL AS BIFUNCTIONAL MODULATORS OF M3 RECEPTORS AND BETA-2 RECEPTORS | ARGENTA DISCOVERY LIMITED (GB) | 2010-02-11 | — | — | WO | disclosed |
| WO-2008096129-A1 | NITROGEN CONTAINING HETROCYCLIC COMPOUNDS USEFUL AS BIFUNCTIONAL MODULATORS OF M3 RECEPTORS AND BETA- 2 RECEPTORS | ARGENTA DISCOVERY LTD (GB) | 2008-08-14 | — | — | WO | disclosed |