SCHEMBL3227714

SCHEMBL3227714

OC(c1ccccc1)(c1ncc(CCNCc2ccccc2)o1)C1CCCCC1

nearest known ligand 0.41

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
SIGMAR1 Q99720 1/20 0.41
HTT P42858 2/20 0.38
NPSR1 Q6W5P4 1/20 0.38
HTR5A P47898 2/20 0.38
NPC1 O15118 1/20 0.37
RAB9A P51151 1/20 0.37
SLC6A4 P31645 2/20 0.36
CHRM3 P20309 9/20 0.36
GAA P10253 1/20 0.36
MAPT P10636 1/20 0.36
CHRM2 P08172 8/20 0.35
CHRM4 P08173 8/20 0.35
CHRM5 P08912 8/20 0.35
CHRM1 P11229 8/20 0.35
MPO P05164 1/20 0.34
HRH4 Q9H3N8 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3227705 1.00 SIGMAR1 (0.41) SIGMAR1HTTNPSR1HTR5ANPC1
SCHEMBL3223958 0.86 CHRM3 (0.40) HTTNPSR1CHRM3CHRM2CHRM4
SCHEMBL14101280 0.86 CHRM3 (0.38) SIGMAR1HTTNPSR1CHRM3CHRM2
SCHEMBL3223966 0.86 CHRM3 (0.40) HTTNPSR1CHRM3CHRM2CHRM4
SCHEMBL27774376 0.82 CHRM3 (0.40) SIGMAR1CHRM3CHRM2CHRM4CHRM5
SCHEMBL27736539 0.82 CHRM3 (0.40) SIGMAR1CHRM3CHRM2CHRM4CHRM5
SCHEMBL3221153 0.82 CHRM3 (0.40) CHRM3CHRM2CHRM4CHRM5CHRM1
SCHEMBL27795281 0.82 CHRM3 (0.40) SIGMAR1CHRM3CHRM2CHRM4CHRM5
SCHEMBL1109823 0.82 CHRM3 (0.40) CHRM3CHRM2CHRM4CHRM5CHRM1
SCHEMBL4741150 0.82 GAA (0.43) SIGMAR1GAAMAPTCHRM2MPO

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2010015792-A1 NITROGEN CONTAINING HETEROCYCLIC COMPOUNDS USEFUL AS BIFUNCTIONAL MODULATORS OF M3 RECEPTORS AND BETA-2 RECEPTORS ARGENTA DISCOVERY LIMITED (GB) 2010-02-11 WO disclosed
WO-2008096129-A1 NITROGEN CONTAINING HETROCYCLIC COMPOUNDS USEFUL AS BIFUNCTIONAL MODULATORS OF M3 RECEPTORS AND BETA- 2 RECEPTORS ARGENTA DISCOVERY LTD (GB) 2008-08-14 WO disclosed