Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.51 |
| ▸ | RAB9A | P51151 | 5/20 | 0.51 |
| ▸ | RIPK1 | Q13546 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.39 |
| ▸ | GID4 | Q8IVV7 | 1/20 | 0.39 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13490707 | 0.95 | NPC1 (0.56) | NPC1RAB9ARIPK1SMN1; SMN2MAPT | |
| SCHEMBL14192818 | 0.86 | NPC1 (0.50) | NPC1RAB9ARIPK1 | |
| SCHEMBL3218426 | 0.86 | NPC1 (0.50) | NPC1RAB9ARIPK1 | |
| Trifluoroacetic Acid SCHEMBL3207659 | 0.85 | NPC1 (0.57) | NPC1RAB9ASMN1; SMN2USP30GID4 | |
| Trifluoroacetic Acid SCHEMBL3223498 | 0.85 | NPC1 (0.57) | NPC1RAB9ASMN1; SMN2USP30GID4 | |
| SCHEMBL13490753 | 0.85 | NPC1 (0.48) | NPC1RAB9ARIPK1 | |
| Hydrochloric Acid SCHEMBL3223688 | 0.85 | NPC1 (0.48) | NPC1RAB9ARIPK1 | |
| SCHEMBL13490693 | 0.80 | NPC1 (0.64) | NPC1RAB9ASMN1; SMN2USP30GID4 | |
| SCHEMBL13490493 | 0.80 | NPC1 (0.64) | NPC1RAB9ASMN1; SMN2USP30GID4 | |
| Trifluoroacetic Acid SCHEMBL3210512 | 0.79 | HTR2B (0.43) | SMN1; SMN2HTR2BGID4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100029615-A1 | BENZIMIDAZOLE DERIVATIVES | PFIZER INC. | 2010-02-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100029615-A1 | BENZIMIDAZOLE DERIVATIVES | ACIN1, HAT1, CCNE1 | NPC1 3250/4885RAB9A 1662/4885RIPK1 4180/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.