Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 1/20 | 0.70 |
| ▸ | CA1 | P00915 | 1/20 | 0.70 |
| ▸ | CA2 | P00918 | 1/20 | 0.70 |
| ▸ | CA9 | Q16790 | 1/20 | 0.70 |
| ▸ | F13A1 | P00488 | 1/20 | 0.70 |
| ▸ | TGM2 | P21980 | 1/20 | 0.70 |
| ▸ | TGM1 | P22735 | 1/20 | 0.70 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.65 |
| ▸ | HSD11B1 | P28845 | 10/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3213283 | 0.91 | CA12 (0.73) | CA12CA1CA2CA9F13A1 | |
| SCHEMBL3221272 | 0.85 | F13A1 (0.77) | CA12CA1CA2CA9F13A1 | |
| SCHEMBL3210360 | 0.83 | HSD11B1 (0.74) | F13A1TGM2TGM1HSD11B1 | |
| SCHEMBL3223739 | 0.83 | F13A1 (0.75) | CA12CA1CA2CA9F13A1 | |
| SCHEMBL1872122 | 0.82 | F13A1 (1.00) | CA12CA1CA2CA9F13A1 | |
| SCHEMBL3224638 | 0.82 | F13A1 (0.73) | CA12CA1CA2CA9F13A1 | |
| SCHEMBL3712104 | 0.80 | TRPV1 (0.80) | CA12CA1CA2CA9TRPV1 | |
| SCHEMBL4262793 | 0.78 | TRPV1 (0.82) | CA12CA1CA2CA9TRPV1 | |
| SCHEMBL3210183 | 0.78 | HSD11B1 (1.00) | HSD11B1 | |
| SCHEMBL19248151 | 0.77 | HSD11B1 (1.00) | HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100029648-A1 | 11-Beta HSD1 Inhibitors | XIANG JASON SHAOYUN | 2010-02-04 | — | — | US | disclosed |
| US-7632838-B2 | 11-beta HSD1 inhibitors | WYETH (US) | 2009-12-15 | — | — | US | disclosed |
| US-20070219198-A1 | 11-Beta HSD 1 inhibitors | WYETH (US) | 2007-09-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100029648-A1 | 11-Beta HSD1 Inhibitors | HSD11B1, HSD3B1, HSD11B2 | CA12 3103/4885CA1 2701/4885CA2 3927/4885 |
| US-20070219198-A1 | 11-Beta HSD 1 inhibitors | HSD11B1, HSD11B2, HSD3B1 | CA12 3314/4885CA1 2569/4885CA2 3774/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.