Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.45 |
| ▸ | PDE10A | Q9Y233 | 14/20 | 0.42 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | RBP4 | P02753 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7943730 | 0.89 | HRH4 (0.42) | HRH4PDE10A | |
| SCHEMBL1550512 | 0.87 | DRD2 (0.42) | HRH4PDE10ASMYD3CNR2 | |
| SCHEMBL3229214 | 0.86 | HRH4 (0.42) | HRH4PDE10ASMYD3 | |
| SCHEMBL1550154 | 0.85 | HRH4 (0.38) | HRH4PDE10ASMYD3CNR2 | |
| SCHEMBL1550076 | 0.85 | HRH4 (0.38) | HRH4PDE10ASMYD3CNR2 | |
| SCHEMBL1550577 | 0.85 | TP53 (0.39) | HRH4PDE10ASMYD3 | |
| SCHEMBL1550196 | 0.84 | NSD2 (0.41) | HRH4PDE10ASMYD3 | |
| SCHEMBL1550329 | 0.84 | HRH4 (0.48) | HRH4PDE10ASMYD3RBP4 | |
| SCHEMBL1550827 | 0.83 | PYGL (0.44) | SMYD3 | |
| SCHEMBL1549669 | 0.83 | HRH4 (0.38) | HRH4PDE10ASMYD3CNR2RBP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2312947-B1 | TRPV4 ANTAGONISTS | GLAXOSMITHKLINE LLC (US) | 2014-01-01 | — | — | EP | disclosed |
| US-8450484-B2 | TRPV4 antagonists | GlaxoSmithKline, LLC (US) | 2013-05-28 | — | — | US | disclosed |
| WO-2010011914-A1 | TRPV4 ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2010-01-28 | — | — | WO | disclosed |