Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 5/20 | 0.59 |
| ▸ | NR1H4 | Q96RI1 | 3/20 | 0.47 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.44 |
| ▸ | CDK2 | P24941 | 1/20 | 0.44 |
| ▸ | HSF1 | Q00613 | 1/20 | 0.44 |
| ▸ | CNR1 | P21554 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 4/20 | 0.42 |
| ▸ | RET | P07949 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | FLT1 | P17948 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | FYN | P06241 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3227236 | 0.85 | S1PR1 (0.57) | S1PR1KDRKCNH2SMN1; SMN2NPC1 | |
| SCHEMBL3230524 | 0.78 | KDR (0.54) | S1PR1NR1H4KDRSMN1; SMN2NPC1 | |
| SCHEMBL3261684 | 0.77 | SMN1; SMN2 (0.60) | S1PR1NR1H4KDRSMN1; SMN2LMNA | |
| SCHEMBL3225448 | 0.76 | S1PR1 (0.47) | S1PR1KDRSMN1; SMN2NPC1RAB9A | |
| SCHEMBL3040423 | 0.74 | S1PR1 (1.00) | S1PR1 | |
| SCHEMBL3229082 | 0.74 | KCNH2 (0.59) | S1PR1KCNH2SMN1; SMN2NPC1RAB9A | |
| SCHEMBL3227860 | 0.74 | EGFR (0.58) | S1PR1KDRKCNH2NPC1RAB9A | |
| SCHEMBL3222813 | 0.73 | EGFR (0.64) | S1PR1KCNH2SMN1; SMN2NPC1RAB9A | |
| SCHEMBL3226154 | 0.73 | S1PR1 (0.61) | S1PR1KDRSMN1; SMN2NPC1RAB9A | |
| SCHEMBL3226839 | 0.72 | S1PR1 (0.62) | S1PR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010020432-A8 | COMPOUNDS FOR TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY | BIOMARIN IGA LIMITED (BS) | 2010-03-11 | — | — | WO | claimed |
| WO-2010020432-A2 | COMPOUNDS FOR TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY | SUMMIT CORPORATION PLC (GB) | 2010-02-25 | — | — | WO | claimed |