Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.59 |
| ▸ | NPC1 | O15118 | 2/20 | 0.55 |
| ▸ | RAB9A | P51151 | 2/20 | 0.55 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.54 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.50 |
| ▸ | ABL1 | P00519 | 1/20 | 0.49 |
| ▸ | BCR | P11274 | 1/20 | 0.49 |
| ▸ | EGFR | P00533 | 3/20 | 0.47 |
| ▸ | ERBB3 | P21860 | 2/20 | 0.47 |
| ▸ | KMO | O15229 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.47 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | AURKA | O14965 | 1/20 | 0.46 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3227860 | 0.90 | EGFR (0.58) | KCNH2NPC1RAB9AS1PR1TNNI3K | |
| SCHEMBL3226154 | 0.88 | S1PR1 (0.61) | NPC1RAB9AS1PR1EGFRERBB3 | |
| SCHEMBL3227236 | 0.88 | S1PR1 (0.57) | KCNH2NPC1RAB9AS1PR1EGFR | |
| SCHEMBL3228067 | 0.86 | EGFR (0.58) | NPC1RAB9AS1PR1EGFRERBB3 | |
| SCHEMBL3221150 | 0.85 | S1PR1 (0.58) | RAB9AS1PR1TNNI3KEGFRERBB3 | |
| SCHEMBL3227055 | 0.85 | S1PR1 (0.58) | RAB9AS1PR1TNNI3KEGFRERBB3 | |
| SCHEMBL3229139 | 0.85 | S1PR1 (0.72) | NPC1RAB9AS1PR1EGFRERBB3 | |
| SCHEMBL3222813 | 0.80 | EGFR (0.64) | KCNH2NPC1RAB9AS1PR1EGFR | |
| SCHEMBL3219928 | 0.80 | NPC1 (0.56) | NPC1RAB9AS1PR1EGFRERBB3 | |
| SCHEMBL3225334 | 0.78 | RAB9A (0.57) | NPC1RAB9AS1PR1LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010020432-A8 | COMPOUNDS FOR TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY | BIOMARIN IGA LIMITED (BS) | 2010-03-11 | — | — | WO | claimed |
| WO-2010020432-A2 | COMPOUNDS FOR TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY | SUMMIT CORPORATION PLC (GB) | 2010-02-25 | — | — | WO | claimed |
| WO-2010020432-A8 | COMPOUNDS FOR TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY | BIOMARIN IGA LIMITED (BS) | 2010-03-11 | — | — | WO | disclosed |
| WO-2010020432-A2 | COMPOUNDS FOR TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY | SUMMIT CORPORATION PLC (GB) | 2010-02-25 | — | — | WO | disclosed |