Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 16/20 | 0.50 |
| ▸ | DPP8 | Q6V1X1 | 10/20 | 0.50 |
| ▸ | DPP9 | Q86TI2 | 10/20 | 0.50 |
| ▸ | FAP | Q12884 | 5/20 | 0.44 |
| ▸ | DPP7 | Q9UHL4 | 5/20 | 0.44 |
| ▸ | KIF11 | P52732 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | PITRM1 | Q5JRX3 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4052407 | 1.00 | DPP4 (0.50) | DPP4DPP8DPP9FAPDPP7 | |
| SCHEMBL1930866 | 0.81 | DPP4 (0.46) | DPP4DPP8DPP9FAPDPP7 | |
| SCHEMBL12552885 | 0.81 | DPP4 (0.46) | DPP4DPP8DPP9FAPDPP7 | |
| SCHEMBL21963795 | 0.77 | PIK3CD (0.46) | DPP4DPP8DPP9 | |
| SCHEMBL21963809 | 0.77 | PIK3CD (0.46) | DPP4DPP8DPP9 | |
| SCHEMBL5036242 | 0.75 | ATM (0.32) | — | |
| SCHEMBL14421482 | 0.72 | DPP4 (0.49) | DPP4DPP8DPP9FAPDPP7 | |
| SCHEMBL8353687 | 0.72 | DPP4 (0.49) | DPP4DPP8DPP9FAPDPP7 | |
| SCHEMBL2227853 | 0.72 | DPP4 (0.43) | DPP4DPP8DPP9FAPDPP7 | |
| SCHEMBL25278211 | 0.71 | DPP4 (0.51) | DPP4DPP8DPP9FAPDPP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2312947-B1 | TRPV4 ANTAGONISTS | GLAXOSMITHKLINE LLC (US) | 2014-01-01 | — | — | EP | disclosed |
| US-8450484-B2 | TRPV4 antagonists | GlaxoSmithKline, LLC (US) | 2013-05-28 | — | — | US | disclosed |
| WO-2010011914-A1 | TRPV4 ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2010-01-28 | — | — | WO | disclosed |
| WO-2010011912-A1 | TRPV4 ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2010-01-28 | — | — | WO | disclosed |
| WO-2009146182-A1 | TRPV4 ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-12-03 | — | — | WO | disclosed |