Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | WDR5 | P61964 | 9/20 | 0.36 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.36 |
| ▸ | CFTR | P13569 | 2/20 | 0.36 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.35 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.35 |
| ▸ | MMP2 | P08253 | 1/20 | 0.35 |
| ▸ | MMP3 | P08254 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1763593 | 0.88 | PDK4 (0.47) | WDR5 | |
| SCHEMBL1840656 | 0.83 | NOTUM (0.44) | MAPTWDR5TRPV1MMP2MMP3 | |
| SCHEMBL1843814 | 0.81 | QDPR (0.40) | MAPTWDR5TRPV1 | |
| SCHEMBL3221067 | 0.80 | MAPT (0.37) | MAPTMMP2MMP3 | |
| SCHEMBL3039806 | 0.80 | QDPR (0.46) | MAPTTRPV1MMP2MMP3 | |
| SCHEMBL1763543 | 0.75 | ADH5 (0.41) | MAPTTRPV1MMP2MMP3 | |
| SCHEMBL24718042 | 0.74 | PDK4 (0.48) | WDR5 | |
| SCHEMBL30798488 | 0.74 | PDK4 (0.48) | WDR5 | |
| SCHEMBL4433323 | 0.74 | MAPT (0.52) | MAPT | |
| SCHEMBL7243682 | 0.74 | MRGPRX4 (0.44) | MAPTTRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010005783-A1 | PYRROLIDINYL AND PIPERIDINYL COMPOUNDS USEFUL AS NHE-1 INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-01-14 | — | — | WO | disclosed |