Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 8/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.63 |
| ▸ | NPC1 | O15118 | 6/20 | 0.54 |
| ▸ | HTT | P42858 | 2/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 5/20 | 0.50 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.50 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.50 |
| ▸ | EGFR | P00533 | 1/20 | 0.49 |
| ▸ | ERBB3 | P21860 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | ELOVL1 | Q9BW60 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | CNR1 | P21554 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3232678 | 0.88 | RAB9A (0.65) | RAB9ASMN1; SMN2ALDH1A1NPC1HTT | |
| SCHEMBL13457037 | 0.88 | SMN1; SMN2 (0.50) | RAB9ASMN1; SMN2ALDH1A1NPC1HTT | |
| SCHEMBL3231464 | 0.87 | RAB9A (0.48) | RAB9ASMN1; SMN2ALDH1A1NPC1HTT | |
| SCHEMBL3232609 | 0.82 | RAB9A (0.55) | RAB9ASMN1; SMN2ALDH1A1NPC1HTT | |
| SCHEMBL3224965 | 0.78 | RAB9A (0.60) | RAB9ASMN1; SMN2ALDH1A1NPC1HTT | |
| SCHEMBL3226753 | 0.77 | LMNA (0.48) | RAB9ASMN1; SMN2ALDH1A1TP53MAPT | |
| SCHEMBL3222586 | 0.76 | IDO1 (0.48) | RAB9ASMN1; SMN2ALDH1A1NPC1TP53 | |
| SCHEMBL3231560 | 0.76 | KCNQ3 (0.54) | RAB9ASMN1; SMN2ALDH1A1NPC1HTT | |
| SCHEMBL3231156 | 0.75 | F10 (0.50) | SMN1; SMN2ALDH1A1HTTMAPK1MAPT | |
| SCHEMBL3226691 | 0.74 | RAB9A (0.51) | RAB9ASMN1; SMN2ALDH1A1NPC1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010020432-A8 | COMPOUNDS FOR TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY | BIOMARIN IGA LIMITED (BS) | 2010-03-11 | — | — | WO | claimed |
| WO-2010020432-A2 | COMPOUNDS FOR TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY | SUMMIT CORPORATION PLC (GB) | 2010-02-25 | — | — | WO | claimed |
| WO-2010020432-A8 | COMPOUNDS FOR TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY | BIOMARIN IGA LIMITED (BS) | 2010-03-11 | — | — | WO | disclosed |
| WO-2010020432-A2 | COMPOUNDS FOR TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY | SUMMIT CORPORATION PLC (GB) | 2010-02-25 | — | — | WO | disclosed |