Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 10/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.42 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.42 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.37 |
| ▸ | MTOR | P42345 | 1/20 | 0.37 |
| ▸ | CCR9 | P51686 | 1/20 | 0.36 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.34 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.34 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8191216 | 0.81 | PTGS2 (0.48) | PTGS2PTGS1 | |
| SCHEMBL27890833 | 0.78 | PTGS2 (0.48) | PTGS2PTGS1ABCC4ABCB11PDE4D | |
| SCHEMBL4030219 | 0.78 | PTGS2 (0.51) | PTGS2PTGS1ABCC4ABCB11PDE4D | |
| SCHEMBL7520699 | 0.77 | PTGS2 (0.47) | PTGS2ENPP2 | |
| SCHEMBL6119422 | 0.77 | ALDH1A1 (0.38) | — | |
| SCHEMBL6603370 | 0.76 | PTGS2 (0.50) | PTGS2PTGS1 | |
| SCHEMBL1640713 | 0.74 | PTGS2 (0.56) | PTGS2PTGS1ABCC4ABCB11PDE4D | |
| SCHEMBL27482511 | 0.72 | PTGS2 (0.46) | PTGS2PTGS1ABCC4ABCB11PDE4D | |
| SCHEMBL14655852 | 0.71 | PTGS2 (0.47) | PTGS2PTGS1ABCC4ABCB11PDE4D | |
| SCHEMBL27482169 | 0.71 | PTGS2 (0.47) | PTGS2PTGS1ABCC4ABCB11PDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015036550-A1 | PROCESS FOR MAKING ETORICOXIB | SYNTHON B.V. (NL) | 2015-03-19 | — | — | WO | disclosed |
| EP-2773618-A1 | AN IMPROVED PROCESS FOR THE PREPARATION OF ETORICOXIB AND POLYMORPHS THEREOF | Cadila Healthcare Limited (IN) | 2014-09-10 | — | — | EP | disclosed |
| WO-2014114352-A1 | PROCESS FOR MAKING ETORICOXIB | SYNTHON BV (NL) | 2014-07-31 | — | — | WO | disclosed |
| EP-2649049-A2 | PRODUCE TO PRODUCE ETORICOXIB | Virdev Intermediates Pvt. Ltd. (IN) | 2013-10-16 | — | — | EP | disclosed |
| WO-2013105106-A1 | AN IMPROVED PROCESS FOR THE PREPARATION OF ETORICOXIB AND POLYMORPHS THEREOF | CADILA HEALTHCARE LIMITED (IN) | 2013-07-18 | — | — | WO | disclosed |
| WO-2012066570-A2 | A PROCESS FOR CYCLOOXYGENASE-2 SELECTIVE INHIBITOR | VIRDEV INTERMEDIATES PVT. LTD. (IN) | 2012-05-24 | — | — | WO | disclosed |
| WO-2012004677-A1 | SOLID STATE FORMS OF ETORICOXIB SALTS | ACTAVIS GROUP PTC EHF (IS) | 2012-01-12 | — | — | WO | disclosed |
| EP-1492770-A1 | OXIDATION PROCESS FOR THE PREPARATION OF INTERMEDIATES USEFUL IN THE SYNTHESIS OF DIARYLPYRIDINES | ZAMBON GROUP S.p.A. (IT) | 2005-01-05 | — | — | EP | disclosed |
| WO-2003051843-A1 | OXIDATION PROCESS FOR THE PREPARATION OF INTERMEDIATES USEFUL IN THE SYNTHESIS OF DIARYLPYRIDINES | ZAMBON GROUP S.P.A. (IT) | 2003-06-26 | — | — | WO | disclosed |
| WO-2001017996-A1 | 1,2,3-THIADIAZOLES AND THEIR USE AS COX-2 INHIBITORS | MERCK FROSST CANADA & CO. (CA) | 2001-03-15 | — | — | WO | disclosed |